TTBK2

Gene Symbol TTBK2
Entrez Gene 146057
Alt Symbol SCA11, TTBK
Species Human
Gene Type protein-coding
Description tau tubulin kinase 2
Other Description tau-tubulin kinase 2
Swissprots Q8IVV1 O94932 Q6IQ55 Q6ZN52
Accessions CAD10237 EAW92581 EAW92582 EAW92583 Q6IQ55 AB020654 BAA74870 AF525400 AAO14996 AK074481 AK131372 BAD18523 BC041876 AAH41876 BC071556 AAH71556 BX648356 CB242184 DQ572375 DQ579742 DQ586356 DQ599476 XM_005254171 XP_005254228 XM_005254173 XP_005254230 XM_006720402 XP_006720465 XM_006720403 XP_006720466 XM_011521267 XP_011519569 XM_011521268 XP_011519570 XM_011521269 XP_011519571 NM_173500 NP_775771
Function Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541}.
Subcellular Location Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}.

TTBK2 293T Cell Transient Overexpression Lysate(Denatured) - H00146057-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

Tau tubulin kinase 2 Overexpression Lysate (Native) - NBP2-05134 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Tau tubulin kinase 2 Overexpression Lysate (Adult Normal) [NBP2-05134] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Tau tubulin kinase 2.

Tau tubulin kinase 2 Overexpression Lysate (Denatured) - H00146057-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human TTBK2 Knockdown Stable Cell Line - CSC-DC016776 from Creative biogene

Category Cell Line
Species Human
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