TTBK2

Gene Symbol	TTBK2
Entrez Gene	146057
Alt Symbol	SCA11, TTBK
Species	Human
Gene Type	protein-coding
Description	tau tubulin kinase 2
Other Description	tau-tubulin kinase 2
Swissprots	Q8IVV1 O94932 Q6IQ55 Q6ZN52
Accessions	CAD10237 EAW92581 EAW92582 EAW92583 Q6IQ55 AB020654 BAA74870 AF525400 AAO14996 AK074481 AK131372 BAD18523 BC041876 AAH41876 BC071556 AAH71556 BX648356 CB242184 DQ572375 DQ579742 DQ586356 DQ599476 XM_005254171 XP_005254228 XM_005254173 XP_005254230 XM_006720402 XP_006720465 XM_006720403 XP_006720466 XM_011521267 XP_011519569 XM_011521268 XP_011519570 XM_011521269 XP_011519571 NM_173500 NP_775771
Function	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541}.
Subcellular Location	Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active mouse Tau tubulin kinase 2 protein fragment - ab125631 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Mouse

Human Tau tubulin kinase 2 full length protein - ab132750 from Abcam Category Protein Source Wheat germ Species Human

TTBK2 Antibody Blocking Peptide - LS-E1456 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TTBK2 Antibody Blocking Peptide - LS-E12326 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TTBK2 Antibody Blocking Peptide - LS-E30648 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Tau tubulin kinase 2 Protein - H00146057-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

TTBK2-Antibody-N-term-Blocking-peptide - BP12162a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Ttbk2 Blocking Peptide - 33R-4581 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TTBK2 - H00146057-P01-02 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

TTBK2 - P5658 from Acris Antibodies Category Protein Prices $1,010.00 Sizes 5 µg Species Human

TTBK2 (C-term) Control Peptide - AP55455CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TTBK2 Peptide - 5021P from ProSci Category Peptide Species Human

TTBK2 fusion protein - ag7108 from Proteintech Group Category Protein Source E. coli-derived, T-HIS Species Human

Recombinant Human Tau Tubulin Kinase 2, GST-tagged - TTBK2-1114H from Creative Biomart Category Protein Species Human

Recombinant Tau-Tubulin Kinase 2 (tTBK2) - RPE723Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Tau-Tubulin Kinase 2 (tTBK2) - RPE723Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Tau-tubulin kinase 2(TTBK2) ,partial - CSB-YP753711HU CSB-EP753711HU CSB-BP753711HU CSB-MP753711HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Tau-Tubulin Kinase 2 Protein (Recombinant) - abx168270 from Abbexa Category Protein Source Human Species Human

TTBK2 Protein - abx163581 from Abbexa Category Protein Species Human, Rat

Tau-Tubulin Kinase 2, Recombinant Protein - MBS2029449 from MyBioSource Category Protein Prices $190.00, $405.00, $625.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

Tau-tubulin kinase 2 (TTBK2), partial, Recombinant Protein - MBS1411696 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Tau tubulin kinase 2 Recombinant Protein Antigen - NBP1-92476PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TTBK2 Peptide, Human - M34GP16776H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Tau-Tubulin Kinase 2 (tTBK2) - RPU53653 from Biomatik Category Protein Prices $198.00, $387.00, $619.00, $738.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

TTBK2 Recombinant Protein (OPCD07744) - OPCD07744 from Aviva Systems Biology Category Protein Source E.coli Species Human

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