TTBK2
| Gene Symbol | TTBK2 |
|---|---|
| Entrez Gene | 146057 |
| Alt Symbol | SCA11, TTBK |
| Species | Human |
| Gene Type | protein-coding |
| Description | tau tubulin kinase 2 |
| Other Description | tau-tubulin kinase 2 |
| Swissprots | Q8IVV1 O94932 Q6IQ55 Q6ZN52 |
| Accessions | CAD10237 EAW92581 EAW92582 EAW92583 Q6IQ55 AB020654 BAA74870 AF525400 AAO14996 AK074481 AK131372 BAD18523 BC041876 AAH41876 BC071556 AAH71556 BX648356 CB242184 DQ572375 DQ579742 DQ586356 DQ599476 XM_005254171 XP_005254228 XM_005254173 XP_005254230 XM_006720402 XP_006720465 XM_006720403 XP_006720466 XM_011521267 XP_011519569 XM_011521268 XP_011519570 XM_011521269 XP_011519571 NM_173500 NP_775771 |
| Function | Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro. {ECO:0000269|PubMed:21548880, ECO:0000269|PubMed:23141541}. |
| Subcellular Location | Cell projection, cilium {ECO:0000250}. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus. Note=Localizes to the transition zone in primary cilia in response to cell cycle signals that promote ciliogenesis (By similarity). May also be present in cytosol and, at lower level in the nucleus. {ECO:0000250}. |
SCA11 CRISPR/Cas9 KO Plasmid (h) - sc-410326 from Santa Cruz Biotechnology
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SCA11 HDR Plasmid (h) - sc-410326-HDR from Santa Cruz Biotechnology
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SCA11 Double Nickase Plasmid (h) - sc-410326-NIC from Santa Cruz Biotechnology
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SCA11 Double Nickase Plasmid (h2) - sc-410326-NIC-2 from Santa Cruz Biotechnology
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SCA11 CRISPR Activation Plasmid (h) - sc-410326-ACT from Santa Cruz Biotechnology
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SCA11 CRISPR Activation Plasmid (h2) - sc-410326-ACT-2 from Santa Cruz Biotechnology
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SCA11 Lentiviral Activation Particles (h) - sc-410326-LAC from Santa Cruz Biotechnology
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SCA11 Lentiviral Activation Particles (h2) - sc-410326-LAC-2 from Santa Cruz Biotechnology
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SCA11 siRNA (h) - sc-90020 from Santa Cruz Biotechnology
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SCA11 shRNA Plasmid (h) - sc-90020-SH from Santa Cruz Biotechnology
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SCA11 shRNA (h) Lentiviral Particles - sc-90020-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU060371 from Sigma-Aldrich
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MISSION® siRNA - SIHK2376 from Sigma-Aldrich
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MISSION® siRNA - SIHK2377 from Sigma-Aldrich
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MISSION® siRNA - SIHK2375 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2556 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2556 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09221 from Sigma-Aldrich
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TTBK2 siRNA (Human) - CRJ5455 from Cohesion Biosciences
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Tau tubulin kinase 2 RNAi - H00146057-R02 from Novus Biologicals
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TTBK2 - MBS8211821 from MyBioSource
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shRNA set against Human TTBK2 (NM_173500.3) - SHH436740 from Creative biogene
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shRNA set against Human TTBK2(NM_173500.3) - SHL101440 from Creative biogene
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Human TTBK2 siRNA - orb275956 from Biorbyt
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TTBK2 shRNA Plasmid (Human) - CHJ5455 from Cohesion Biosciences
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