| Gene Symbol |
NELFA
|
| Entrez Gene |
7469
|
| Alt Symbol |
NELF-A, P/OKcl.15, WHSC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative elongation factor complex member A
|
| Other Description |
negative elongation factor A|wolf-Hirschhorn syndrome candidate 2 protein
|
| Swissprots |
A2A2T1 Q9H3P2 O95392
|
| Accessions |
EAW82545 EAW82546 EAW82547 Q9H3P2 AB044549 BAB18651 AF101434 AAC72982 AF131751 AAD20034 AI218582 AI560345 AK001304 BAG50890 AK094040 BAG52802 AK095737 BAG53117 AK126056 BAG54283 AK222853 BAD96573 BC002764 AAH02764 DB082393 EU831413 ACE87100 EU831506 ACE86425 XM_006713916 XP_006713979 XM_011513561 XP_011511863 NM_005663 NP_005654
|
| Function |
Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex. {ECO:0000269|PubMed:10199401, ECO:0000269|PubMed:12563561, ECO:0000269|PubMed:12612062}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11150502}.
|
| Tissue Specificity |
Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney. {ECO:0000269|PubMed:10409432, ECO:0000269|PubMed:11150502, ECO:0000269|PubMed:12612062}.
|