| Gene Symbol | MPP5 |
|---|---|
| Entrez Gene | 64398 |
| Alt Symbol | PALS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) |
| Other Description | MAGUK p55 subfamily member 5|protein associated with lin seven 1|stardust |
| Swissprots | Q8N7I5 Q7Z631 Q9H9Q0 Q86T98 Q8N3R9 A1L380 |
| Accessions | CAD22414 CAD22415 EAW80930 Q8N3R9 AF131764 AI245706 AK022677 BAB14172 AK057160 AK098373 BAC05295 AK291240 BAF83929 AL832326 CAD38620 AL832578 CAD89937 AL832936 CAH56281 AM392599 CAL37477 AM392859 CAL37737 BC037966 BC053366 AAH53366 BC095485 AAH95485 BC129933 AAI29934 DA095710 DR003886 XM_005268003 XP_005268060 XM_011537086 XP_011535388 XM_011537087 XP_011535389 NM_001256550 NP_001243479 NM_022474 NP_071919 |
| Function | May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon. |
| Tissue Specificity | Expressed in the retina (at protein level). {ECO:0000269|PubMed:15558731, ECO:0000269|PubMed:15914641}. |
| Top Pathways | Tight junction, Hippo signaling pathway |