MPP5
| Gene Symbol | MPP5 |
|---|---|
| Entrez Gene | 64398 |
| Alt Symbol | PALS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5) |
| Other Description | MAGUK p55 subfamily member 5|protein associated with lin seven 1|stardust |
| Swissprots | Q8N7I5 Q7Z631 Q9H9Q0 Q86T98 Q8N3R9 A1L380 |
| Accessions | CAD22414 CAD22415 EAW80930 Q8N3R9 AF131764 AI245706 AK022677 BAB14172 AK057160 AK098373 BAC05295 AK291240 BAF83929 AL832326 CAD38620 AL832578 CAD89937 AL832936 CAH56281 AM392599 CAL37477 AM392859 CAL37737 BC037966 BC053366 AAH53366 BC095485 AAH95485 BC129933 AAI29934 DA095710 DR003886 XM_005268003 XP_005268060 XM_011537086 XP_011535388 XM_011537087 XP_011535389 NM_001256550 NP_001243479 NM_022474 NP_071919 |
| Function | May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon. |
| Tissue Specificity | Expressed in the retina (at protein level). {ECO:0000269|PubMed:15558731, ECO:0000269|PubMed:15914641}. |
| Top Pathways | Tight junction, Hippo signaling pathway |
Pals1 CRISPR/Cas9 KO Plasmid (h) - sc-403059 from Santa Cruz Biotechnology
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Pals1 HDR Plasmid (h) - sc-403059-HDR from Santa Cruz Biotechnology
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Pals1 Double Nickase Plasmid (h) - sc-403059-NIC from Santa Cruz Biotechnology
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Pals1 Double Nickase Plasmid (h2) - sc-403059-NIC-2 from Santa Cruz Biotechnology
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Pals1 CRISPR Activation Plasmid (h) - sc-403059-ACT from Santa Cruz Biotechnology
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Pals1 CRISPR Activation Plasmid (h2) - sc-403059-ACT-2 from Santa Cruz Biotechnology
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Pals1 Lentiviral Activation Particles (h) - sc-403059-LAC from Santa Cruz Biotechnology
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Pals1 Lentiviral Activation Particles (h2) - sc-403059-LAC-2 from Santa Cruz Biotechnology
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Pals1 siRNA (h) - sc-43991 from Santa Cruz Biotechnology
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Pals1 shRNA Plasmid (h) - sc-43991-SH from Santa Cruz Biotechnology
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Pals1 shRNA (h) Lentiviral Particles - sc-43991-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU042571 from Sigma-Aldrich
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MISSION® siRNA - SIHK1325 from Sigma-Aldrich
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MISSION® siRNA - SIHK1326 from Sigma-Aldrich
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MISSION® siRNA - SIHK1327 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14506 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14506 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00036 from Sigma-Aldrich
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MPP5 siRNA (Human) - CRJ2003 from Cohesion Biosciences
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PALS1/MPP5 RNAi - H00064398-R01 from Novus Biologicals
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shRNA set against Human MPP5 (NM_022474.3) - SHH343968 from Creative biogene
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Human MPP5 siRNA - orb272504 from Biorbyt
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MPP5 shRNA Plasmid (Human) - CHJ2003 from Cohesion Biosciences
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MPP5 miRNA 3'UTR clone - MiUTR4H-TG05604 from Creative biogene
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