MPP5

Gene Symbol MPP5
Entrez Gene 64398
Alt Symbol PALS1
Species Human
Gene Type protein-coding
Description membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
Other Description MAGUK p55 subfamily member 5|protein associated with lin seven 1|stardust
Swissprots Q8N7I5 Q7Z631 Q9H9Q0 Q86T98 Q8N3R9 A1L380
Accessions CAD22414 CAD22415 EAW80930 Q8N3R9 AF131764 AI245706 AK022677 BAB14172 AK057160 AK098373 BAC05295 AK291240 BAF83929 AL832326 CAD38620 AL832578 CAD89937 AL832936 CAH56281 AM392599 CAL37477 AM392859 CAL37737 BC037966 BC053366 AAH53366 BC095485 AAH95485 BC129933 AAI29934 DA095710 DR003886 XM_005268003 XP_005268060 XM_011537086 XP_011535388 XM_011537087 XP_011535389 NM_001256550 NP_001243479 NM_022474 NP_071919
Function May play a role in tight junctions biogenesis and in the establishment of cell polarity in epithelial cells. May modulate SC6A1/GAT1-mediated GABA uptake by stabilizing the transporter. Required for localization of EZR to the apical membrane of parietal cells and may play a role in the dynamic remodeling of the apical cytoskeleton (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Peripheral membrane protein. Endomembrane system; Peripheral membrane protein. Cell junction, tight junction. Note=Localized to the tight junctions of epithelial cells and a subset of intracellular vesicles. In the retina, detected at the outer limiting membrane (OLM), apical to the adherens junction (AJ), where it colocalizes with CRB1. Colocalizes with MPP1 in the retina at the outer limiting membrane (OLM). Localized to the Purkinje cell body and axon.
Tissue Specificity Expressed in the retina (at protein level). {ECO:0000269|PubMed:15558731, ECO:0000269|PubMed:15914641}.
Top Pathways Tight junction, Hippo signaling pathway

Pals1 (H-250) - sc-33831 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Pals1 (H-250): sc-33831. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic and apical membrane staining of glandular cells.

Pals1 (G-5) - sc-365411 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Pals1 (G-5): sc-365411. Western blot analysis of Pals1 expression in ARPE-19 whole cell lysate.

Pals1 (V-18) - sc-28448 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Pals1 (W-15) - sc-28447 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Pals1 (W-15): sc-28447. Immunoperoxidase staining of formalin fixed, paraffin-embedded human fallopian tube tissue showing cytoplasmic and apical membrane staining of glandular cells.

Anti-MPP5 antibody - ab106850 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MPP5 antibody (ab106850) at 1 µg/ml (Milk blocking - 3%)Lane 1 : Mouse Hippocampus Tissue Lysate Lane 2 : Cerebellum Mouse Tissue LysateLane 3 : Lung (Mouse) Whole Cell Lysate - normal tissue (ab29297)Lane 4 : Brain (Mouse) Tissue Lysate Lane 5 : Mouse Sciatic Nerve Tissue LysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-MPP5 antibody - ab20511 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-MPP5 antibody (ab20511) at 1 µg/ml + Human brain lysate at 35 µgdeveloped using the ECL technique

Anti-MPP5 antibody - ab113243 from Abcam

Prices $407.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MPP5 antibody (ab113243) at 1/500 dilution + 293T whole cell lysate at 30 µg

Anti-MPP5 antibody - ab200154 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MPP5 antibody (ab200154) at 1/1000 dilutionLane 1 : Mouse brain total cell extractLane 2 : HeLa total cell extract

Anti-MPP5 antibody - ab83891 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-MPP5 antibody (ab83891) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-MPP5 antibody - ab56405 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab56405 MPP5 antibody at 1ug/ml.

Anti-MPP5 antibody - N-terminal - ab155132 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-MPP5 antibody - N-terminal (ab155132) at 1/500 dilutionLane 1 : U87-MG whole cell lysateLane 2 : SK-N-SH whole cell lysateLysates/proteins at 30 µg per lane.

Anti-MPP5 Antibody (clone 2D3) - LS-C173819 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D3
Western blot of extracts (35 ug) from 9 different cell lines by using anti-MPP5 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

Anti-MPP5 Antibody (aa79-178) - LS-C309234 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-MPP5 Antibody - LS-C311402 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MPP5 Antibody (aa575-624) - LS-C108053 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MPP5 antibody LS-C108053 Western blot of ACHN lysate.

Anti-MPP5 Antibody (aa36-85) - LS-C101989 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
MPP5 antibody LS-C101989 Western blot of Jurkat lysate.

Anti-MPP5 Antibody (clone 5E10) - LS-C173824 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5E10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MPP5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MPP5.

Anti-MPP5 Antibody (clone 5D10) - LS-C173823 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5D10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MPP5 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MPP5.

Anti-MPP5 Antibody (aa455-675) - LS-C314603 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant MPP5.

Anti-MPP5 Antibody (aa174-187) IHC-plus™ - LS-B2285 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MPP5 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2285 concentration 5 ug/ml.

Anti-MPP5 Antibody (aa450-461) IHC-plus™ - LS-B11316 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MPP5 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B11316 dilution 1:100.

Anti-MPP5 Antibody IHC-plus™ - LS-B4831 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MPP5 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4831 concentration 10 ug/ml.

PALS1/MPP5 Antibody - AF7979 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Western blot shows lysates of HeLa human cervical epithelial carcinoma cell line, MCF‑7 human breast cancer cell line, bEnd.3 mouse endothelioma cell line, and Rat‑2 rat embryonic fibroblast cell line. PVDF membrane was probed with 0.5 µg/mL of Sheep Anti-Human/Mouse/Rat PALS1/MPP5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF7979) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # HAF016). Specific bands were detected for PALS1/MPP5 at approximately 75-80 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PALS1/MPP5 Antibody (2D3) - NBP2-01880 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2D3
Western Blot: MPP5 Antibody (2D3) [NBP2-01880] Analysis of extracts (35ug) from 9 different cell lines by using anti-MPP5 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

PALS1/MPP5 Antibody - NBP1-54724 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PALS1/MPP5 Antibody [NBP1-54724] - Human Fetal Liver, Antibody Dilution: 1.0 ug/ml.
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