IL1RAP

Gene Symbol IL1RAP
Entrez Gene 3556
Alt Symbol C3orf13, IL-1RAcP, IL1R3
Species Human
Gene Type protein-coding
Description interleukin 1 receptor accessory protein
Other Description IL-1 receptor accessory protein|IL-1R3|interleukin-1 receptor 3|interleukin-1 receptor accessory protein|interleukin-1 receptor accessory protein beta
Swissprots Q86WJ7 D3DNW0 B1NLD0 Q9NPH3 O14915
Accessions AAC39609 AAF71688 AAF71689 EAW78100 EAW78101 EAW78102 EAW78103 Q9NPH3 AB006537 BAA25421 AF029213 AAB84059 AF167343 AAF71687 AF487335 AAO49451 AF538730 AAQ01755 AF538731 AAQ01756 AF538732 AAQ01757 AF538733 AAQ01758 AF538734 AAQ01759 AK095107 BAC04487 AK291669 BAF84358 BC016141 BC053621 AAH53621 BG032519 BM194193 BM760155 BM973472 DA024801 DN990628 EF591790 ABU90811 FJ998418 ACR82488 HQ448120 ADQ32601 XM_005247433 XP_005247490 XM_005247434 XP_005247491 XM_011512794 XP_011511096 NM_001167928 NP_001161400 NM_001167929 NP_001161401 NM_001167930 NP_001161402 NM_001167931 NP_001161403 NM_002182 NP_002173 NM_134470 NP_608273
Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:000
Subcellular Location Isoform 3: Secreted.
Tissue Specificity Detected in liver, skin, placenta, thymus and lung. {ECO:0000269|PubMed:12530978}.
Top Pathways Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels

IL-1RAcP (D-5) - sc-376872 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IL-1RAcP (D-5): sc-376872. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic and membrane localization.

IL-1RAcP (H-128) - sc-99031 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

IL-1RAcP (N-20) - sc-47056 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IL-1RAcP (N-20): sc-47056. Western blot analysis of IL-1RAcP expression in non-transfected: sc-117752 (A) and human IL-1RAcP transfected: sc-116546 (B) 293T whole cell lysates.

IL-1RAcP (R-16) - sc-47057 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IL1RAP antibody - ab8110 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL1RAP antibody (ab8110) at 1/1000 dilution + HeLa whole cell lysateObserved band size : 66 kDa (why is the actual band size different from the predicted?)

Anti-IL1RAP antibody - ab8109 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IL1RAP antibody (ab8109) at 1/500 dilution + Hela whole cell lysateObserved band size : 66 kDa (why is the actual band size different from the predicted?)

Anti-IL1RAP antibody - ab154382 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-IL1RAP antibody (ab154382) at 1/1000 dilution + Jurkat whole cell lysate at 30 µg

Anti-IL1RAP Antibody (aa525-540) - LS-C24851 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody (aa351-360) - LS-C3273 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody (clone 3D9) - LS-C197511 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D9

Anti-IL1RAP Antibody (aa65-249, Biotin) - LS-C297823 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody (aa65-249, FITC) - LS-C305221 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody - LS-C310752 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody - LS-C342252 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-IL1RAP Antibody (aa525-540) - LS-C310 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot of IL-1RAcP in HeLa whole cell lysate with IL-1RAcP antibody at 1:1000 dilution.

Anti-IL1RAP Antibody (aa65-249) - LS-C294791 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant IL-1RAcP / IL1RAP.

Anti-IL1RAP Antibody (C-Terminus) - LS-C311 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunocytochemistry of IL-1RAcP in HeLa cells with IL-1RAcP antibody at 5 µg/ml.

IL-1 RAcP/IL-1 R3 Antibody [Unconjugated] - AF676 from Novus Biologicals

Prices $99.00, $365.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal

IL-1 RAcP/IL-1 R3 Antibody (89412) - MAB676 from Novus Biologicals

Prices $99.00, $269.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 89412
Human peripheral blood monocytes were stained with Human IL‑1 RAcP/IL‑1 R3 Monoclonal Antibody (Catalog # MAB676, filled histogram) or isotype control antibody (Catalog # MAB002, open histogram), followed by Phycoerythrin-conjugated Anti-Mouse IgG F(ab')2 Secondary Antibody (Catalog # F0102B).

IL-1 RAcP/IL-1 R3 Antibody - NBP2-16946 from Novus Biologicals

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IL1RAP Antibody [NBP2-16946] - Sample (30 ug of whole cell lysate) A: Jurkat 7. 5% SDS PAGE gel, diluted at 1:1000.

IL-1 alpha/IL-1F1 Antibody - NBP2-16940 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: IL1 alpha Antibody [NBP2-16940] - Sample (30 ug of whole cell lysate) A: Molt-4 12% SDS PAGE gel, diluted at 1:500.

IL-1 RAcP/IL-1 R3 Antibody - NBP1-76924 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

IL-1 RAcP/IL-1 R3 Antibody (2A3) - H00003556-M06 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2A3
Immunoprecipitation: IL-1 RAcP/IL-1 R3 Antibody (2A3) [H00003556-M06] - Analysis of IL1RAP transfected lysate using anti-IL1RAP monoclonal antibody and Protein A Magnetic Bead, and immunoblotted with IL1RAP rabbit polyclonal antibody.

IL-1 RAcP/IL-1 R3 Antibody - NB100-94363 from Novus Biologicals

Prices $419.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IL1RAP Antibody [NB100-94363] - Western blot analysis of IRAK in THP-1 (THP) and HeLa (HL) whole cell lysates with anti-IRAK at 1:2000 dilution.

IL-1 RAcP/IL-1 R3 Antibody - NBP1-76464 from Novus Biologicals

Prices $299.00, $329.00
Sizes 50 µg, 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: IL-1 RAcP/IL-1 R3 Antibody [NBP1-76464] - Analysis of IL1RAP in HeLa whole cell lysate with anti-IL1RAP (C2) using NBP1-76464 at 1:1000 dilution.
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