IL1RAP

Gene Symbol IL1RAP
Entrez Gene 3556
Alt Symbol C3orf13, IL-1RAcP, IL1R3
Species Human
Gene Type protein-coding
Description interleukin 1 receptor accessory protein
Other Description IL-1 receptor accessory protein|IL-1R3|interleukin-1 receptor 3|interleukin-1 receptor accessory protein|interleukin-1 receptor accessory protein beta
Swissprots Q86WJ7 D3DNW0 B1NLD0 Q9NPH3 O14915
Accessions AAC39609 AAF71688 AAF71689 EAW78100 EAW78101 EAW78102 EAW78103 Q9NPH3 AB006537 BAA25421 AF029213 AAB84059 AF167343 AAF71687 AF487335 AAO49451 AF538730 AAQ01755 AF538731 AAQ01756 AF538732 AAQ01757 AF538733 AAQ01758 AF538734 AAQ01759 AK095107 BAC04487 AK291669 BAF84358 BC016141 BC053621 AAH53621 BG032519 BM194193 BM760155 BM973472 DA024801 DN990628 EF591790 ABU90811 FJ998418 ACR82488 HQ448120 ADQ32601 XM_005247433 XP_005247490 XM_005247434 XP_005247491 XM_011512794 XP_011511096 NM_001167928 NP_001161400 NM_001167929 NP_001161401 NM_001167930 NP_001161402 NM_001167931 NP_001161403 NM_002182 NP_002173 NM_134470 NP_608273
Function Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:000
Subcellular Location Isoform 3: Secreted.
Tissue Specificity Detected in liver, skin, placenta, thymus and lung. {ECO:0000269|PubMed:12530978}.
Top Pathways Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels

IL-1RAcP CRISPR/Cas9 KO Plasmid (h) - sc-402026 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP HDR Plasmid (h) - sc-402026-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP Double Nickase Plasmid (h) - sc-402026-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP Double Nickase Plasmid (h2) - sc-402026-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP CRISPR Activation Plasmid (h) - sc-402026-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP CRISPR Activation Plasmid (h2) - sc-402026-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP Lentiviral Activation Particles (h) - sc-402026-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP Lentiviral Activation Particles (h2) - sc-402026-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

IL-1RAcP siRNA (h) - sc-60831 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-1RAcP shRNA Plasmid (h) - sc-60831-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-1RAcP shRNA (h) Lentiviral Particles - sc-60831-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

IL-1 RAcP/IL-1 R3 RNAi - H00003556-R04 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

IL-1 RAcP/IL-1 R3 RNAi - H00003556-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU158741 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU092051 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU100511 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10598 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10598 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IL1RAP siRNA (Human) - CRH2374 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL1RAP - MBS8240372 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IL1RAP (NM_002182.3) - SHH318569 from Creative biogene

Category siRNA
Species Reactivities Human

Human IL1RAP siRNA - orb262876 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IL1RAP shRNA Plasmid (Human) - CHH2374 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IL1RAP miRNA 3'UTR clone - MiUTR3H-05143 from Creative biogene

Species Reactivities Human
Search more