IL1RAP

Gene Symbol	IL1RAP
Entrez Gene	3556
Alt Symbol	C3orf13, IL-1RAcP, IL1R3
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor accessory protein
Other Description	IL-1 receptor accessory protein|IL-1R3|interleukin-1 receptor 3|interleukin-1 receptor accessory protein|interleukin-1 receptor accessory protein beta
Swissprots	Q86WJ7 D3DNW0 B1NLD0 Q9NPH3 O14915
Accessions	AAC39609 AAF71688 AAF71689 EAW78100 EAW78101 EAW78102 EAW78103 Q9NPH3 AB006537 BAA25421 AF029213 AAB84059 AF167343 AAF71687 AF487335 AAO49451 AF538730 AAQ01755 AF538731 AAQ01756 AF538732 AAQ01757 AF538733 AAQ01758 AF538734 AAQ01759 AK095107 BAC04487 AK291669 BAF84358 BC016141 BC053621 AAH53621 BG032519 BM194193 BM760155 BM973472 DA024801 DN990628 EF591790 ABU90811 FJ998418 ACR82488 HQ448120 ADQ32601 XM_005247433 XP_005247490 XM_005247434 XP_005247491 XM_011512794 XP_011511096 NM_001167928 NP_001161400 NM_001167929 NP_001161401 NM_001167930 NP_001161402 NM_001167931 NP_001161403 NM_002182 NP_002173 NM_134470 NP_608273
Function	Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:000
Subcellular Location	Isoform 3: Secreted.
Tissue Specificity	Detected in liver, skin, placenta, thymus and lung. {ECO:0000269|PubMed:12530978}.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human IL1RAP ELISA Kit (Sandwich ELISA) - LS-F6689 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Mouse IL1RAP ELISA Kit (Sandwich ELISA) - LS-F6942 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 31.25 pg/ml Range 0.156-10 ng/ml

Human IL1RAP / Interleukin-1 Receptor Accessory Protein ELISA Kit - RAB0690 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human IL-1 RAcP/IL-1 R3 DuoSet ELISA - DY676 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 31.20 - 2,000 pg/mL

Human IL1RAP ELISA Kit - abx151936 from Abbexa Category ELISA Kit Sensitivity 0.065 ng/ml Range 0.156 ng/ml - 10 ng/ml

Interleukin 1 Receptor Accessory Protein (IL1RAP), Human, ELISA Kit - SEH819Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.065ng/mL Range 0.156-10ng/mL

Interleukin-1 receptor accessory protein (IL1RAP), Human, ELISA Kit - CSB-EL011623HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Interleukin 1 Receptor Accessory Protein (IL1RAP), Human, CLIA Kit - SCH819Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 30.2pg/mL Range 93.75-6,000pg/mL

IL1RAP (Human) IP-WB Antibody Pair - H00003556-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Custom Human IL-1R3 ELISA - ELH-IL1R3 from RayBiotech Category ELISA Kit Prices $615.00, $1,107.00, $2,460.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Human IL-1Racp ELISA Kit - HI0314 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine IL-1Racp ELISA Kit - AI0314 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Interleukin 1 Racp, ELISA Kit - MBS734215 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Racp, ELISA Kit - MBS730894 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Racp, ELISA Kit - MBS720693 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive) Sensitivity 1.0 pg/mL.

Interleukin 1 Racp, ELISA Kit - MBS722755 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Racp, ELISA Kit - MBS743768 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Racp, ELISA Kit - MBS738986 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Racp, ELISA Kit - MBS739242 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Racp, ELISA Kit - MBS729799 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Interleukin 1 Racp, ELISA Kit - MBS737772 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Interleukin 1 Racp, ELISA Kit - MBS737776 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Racp, ELISA Kit - MBS742136 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Interleukin 1 Racp, ELISA Kit - MBS733695 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,850.00, $5,340.00 Sizes 48 -strip-wells- (Competitive), 96 -strip-wells- (Competitive), 5x96-strip-wells- (Competitive), 10x96-strip-wells- (Competitive)

interleukin 1 receptor accessory protein, ELISA Kit - MBS916248 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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