IL1RAP

Gene Symbol	IL1RAP
Entrez Gene	3556
Alt Symbol	C3orf13, IL-1RAcP, IL1R3
Species	Human
Gene Type	protein-coding
Description	interleukin 1 receptor accessory protein
Other Description	IL-1 receptor accessory protein|IL-1R3|interleukin-1 receptor 3|interleukin-1 receptor accessory protein|interleukin-1 receptor accessory protein beta
Swissprots	Q86WJ7 D3DNW0 B1NLD0 Q9NPH3 O14915
Accessions	AAC39609 AAF71688 AAF71689 EAW78100 EAW78101 EAW78102 EAW78103 Q9NPH3 AB006537 BAA25421 AF029213 AAB84059 AF167343 AAF71687 AF487335 AAO49451 AF538730 AAQ01755 AF538731 AAQ01756 AF538732 AAQ01757 AF538733 AAQ01758 AF538734 AAQ01759 AK095107 BAC04487 AK291669 BAF84358 BC016141 BC053621 AAH53621 BG032519 BM194193 BM760155 BM973472 DA024801 DN990628 EF591790 ABU90811 FJ998418 ACR82488 HQ448120 ADQ32601 XM_005247433 XP_005247490 XM_005247434 XP_005247491 XM_011512794 XP_011511096 NM_001167928 NP_001161400 NM_001167929 NP_001161401 NM_001167930 NP_001161402 NM_001167931 NP_001161403 NM_002182 NP_002173 NM_134470 NP_608273
Function	Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity). Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1- dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non- signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand- bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. {ECO:000
Subcellular Location	Isoform 3: Secreted.
Tissue Specificity	Detected in liver, skin, placenta, thymus and lung. {ECO:0000269|PubMed:12530978}.
Top Pathways	Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

IL1RAP-Over-expression-Lysate - LY12782a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

IL1RAP overexpression lysate - LY400791 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

IL1RAP overexpression lysate - LY408731 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

IL1RAP 293 Cell Lysate - 404753 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

IL1RAP 293 Cell Lysate - 400758 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

IL-1 RAcP/IL-1 R3 Overexpression Lysate (Native) - NBL1-11930 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

IL-1 RAcP/IL-1 R3 Overexpression Lysate (Native) - NBL1-11929 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

IL-1RAcP (h): 293T Lysate - sc-116546 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

IL1RAP Over-expression Lysate Product - GWB-C569D9 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

IL1RAP Over-expression Lysate Product - GWB-1D1C0E from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

Human IL-1RAcP / IL-1R3 HEK293 Cell Lysate (WB positive control) - 10121-H08HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL-1RAcP / IL-1R3 HEK293 Cell Lysate (WB positive control) - 10121-H03HL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human IL1R3 Human Cells Transfected Lysate (positive control) (denatured) - orb173273 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

Human IL1R3 Human Cells Transfected Lysate (positive control) (denatured) - orb173117 from Biorbyt Category Cell Lysate Prices $425.00 Sizes 300 μg Species Human

IL-1 RAcP/IL-1 R3 Overexpression Lysate (Denatured) - H00003556-T02 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

Panoply™ Human IL1RAP Knockdown Stable Cell Line - CSC-DC007564 from Creative biogene Category Cell Line Species Human

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