| Gene Symbol |
RNF216
|
| Entrez Gene |
54476
|
| Alt Symbol |
CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 216
|
| Other Description |
E3 ubiquitin-protein ligase RNF216|triad domain-containing protein 3|ubiquitin-conjugating enzyme 7-interacting protein 1|zinc finger protein inhibiting NF-kappa-B
|
| Swissprots |
Q7Z2H7 Q6Y691 Q9NWF9 Q8NHW7 Q75ML7 Q9NYT1 Q7Z7C1
|
| Accessions |
AAS07532 EAW87347 EAW87348 EAW87349 Q9NWF9 AF228527 AAF36723 AF513717 AAP47174 AF513718 AAP47175 AK000916 BAA91422 AK024787 AK092767 AK123635 BAG53927 AK128551 AK292396 BAF85085 AK297231 BAG59714 AK297416 BAG59849 AK314332 BAG36978 AM392630 CAL37508 AM393688 CAL38564 AY062174 AAL38043 AY177396 AAO60361 AY177397 AAO60362 AY177398 AAO60363 BC000787 AAH00787 BC004947 BC040728 BC063825 AAH63825 BM793093 BM970811 BM997118 BQ018569 BX537406 CAD97648 XM_005249785 XP_005249842 XM_006715748 XP_006715811 XM_011515434 XP_011513736 XM_011515435 XP_011513737 XM_011515436 XP_011513738 XR_242090 NM_207111 NP_996994 NM_207116 NP_996999 NM_019011
|
| Function |
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.
|
| Subcellular Location |
Cytoplasm.
|
| Tissue Specificity |
Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.
|