RNF216

Gene Symbol	RNF216
Entrez Gene	54476
Alt Symbol	CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
Species	Human
Gene Type	protein-coding
Description	ring finger protein 216
Other Description	E3 ubiquitin-protein ligase RNF216|triad domain-containing protein 3|ubiquitin-conjugating enzyme 7-interacting protein 1|zinc finger protein inhibiting NF-kappa-B
Swissprots	Q7Z2H7 Q6Y691 Q9NWF9 Q8NHW7 Q75ML7 Q9NYT1 Q7Z7C1
Accessions	AAS07532 EAW87347 EAW87348 EAW87349 Q9NWF9 AF228527 AAF36723 AF513717 AAP47174 AF513718 AAP47175 AK000916 BAA91422 AK024787 AK092767 AK123635 BAG53927 AK128551 AK292396 BAF85085 AK297231 BAG59714 AK297416 BAG59849 AK314332 BAG36978 AM392630 CAL37508 AM393688 CAL38564 AY062174 AAL38043 AY177396 AAO60361 AY177397 AAO60362 AY177398 AAO60363 BC000787 AAH00787 BC004947 BC040728 BC063825 AAH63825 BM793093 BM970811 BM997118 BQ018569 BX537406 CAD97648 XM_005249785 XP_005249842 XM_006715748 XP_006715811 XM_011515434 XP_011513736 XM_011515435 XP_011513737 XM_011515436 XP_011513738 XR_242090 NM_207111 NP_996994 NM_207116 NP_996999 NM_019011
Function	Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRIAD3 peptide - ab39886 from Abcam Category Peptide Species Human

RNF216 / TRIAD3 Antibody Blocking Peptide - LS-E6856 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF216 / TRIAD3 Antibody Blocking Peptide - LS-E30084 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RNF216 / TRIAD3 Antibody Blocking Peptide - LS-E21138 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRIAD3 Peptide - P0872 from Novus Biologicals Category Peptide Species Human

TRIAD3-UBCE7IP1-Antibody-C-term-Blocking-peptide - BP2106b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF216 Control Peptide - AP30944CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

TRIAD3A Peptide - 3371P from ProSci Category Peptide Species Human

RNF216 fusion protein - Ag0238 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human E3 ubiquitin-protein ligase RNF216(RNF216) ,partial - CSB-YP865157HU CSB-EP865157HU CSB-BP865157HU CSB-MP865157HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

TRIAD3 Recombinant Protein Antigen - NBP1-86907PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

TRIAD3 Protein - NBP1-86906PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

TRIAD3-UBCE7IP1-Antibody-N-term-Blocking-peptide - BP2106a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF216 Peptide, Human - M34GP13422H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RNF216 (RNF216), partial, Recombinant Protein - MBS1455232 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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