RNF216

Gene Symbol	RNF216
Entrez Gene	54476
Alt Symbol	CAHH, TRIAD3, U7I1, UBCE7IP1, ZIN
Species	Human
Gene Type	protein-coding
Description	ring finger protein 216
Other Description	E3 ubiquitin-protein ligase RNF216|triad domain-containing protein 3|ubiquitin-conjugating enzyme 7-interacting protein 1|zinc finger protein inhibiting NF-kappa-B
Swissprots	Q7Z2H7 Q6Y691 Q9NWF9 Q8NHW7 Q75ML7 Q9NYT1 Q7Z7C1
Accessions	AAS07532 EAW87347 EAW87348 EAW87349 Q9NWF9 AF228527 AAF36723 AF513717 AAP47174 AF513718 AAP47175 AK000916 BAA91422 AK024787 AK092767 AK123635 BAG53927 AK128551 AK292396 BAF85085 AK297231 BAG59714 AK297416 BAG59849 AK314332 BAG36978 AM392630 CAL37508 AM393688 CAL38564 AY062174 AAL38043 AY177396 AAO60361 AY177397 AAO60362 AY177398 AAO60363 BC000787 AAH00787 BC004947 BC040728 BC063825 AAH63825 BM793093 BM970811 BM997118 BQ018569 BX537406 CAD97648 XM_005249785 XP_005249842 XM_006715748 XP_006715811 XM_011515434 XP_011513736 XM_011515435 XP_011513737 XM_011515436 XP_011513738 XR_242090 NM_207111 NP_996994 NM_207116 NP_996999 NM_019011
Function	Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down- regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis. {ECO:0000269|PubMed:15107846, ECO:0000269|PubMed:19893624}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Ubiquitous, with the highest levels of expression in testis and peripheral blood leukocytes.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

TRIAD3 CRISPR/Cas9 KO Plasmid (h) - sc-408891 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 HDR Plasmid (h) - sc-408891-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 Double Nickase Plasmid (h) - sc-408891-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 Double Nickase Plasmid (h2) - sc-408891-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 CRISPR Activation Plasmid (h) - sc-408891-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 CRISPR Activation Plasmid (h2) - sc-408891-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 Lentiviral Activation Particles (h) - sc-408891-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 Lentiviral Activation Particles (h2) - sc-408891-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

TRIAD3 siRNA (h) - sc-76730 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIAD3 shRNA Plasmid (h) - sc-76730-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

TRIAD3 shRNA (h) Lentiviral Particles - sc-76730-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU062701 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18422 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18422 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11854 from Sigma-Aldrich Category miRNA

RNF216 siRNA (Human) - CRJ0083 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RNF216 - MBS8238917 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RNF216 (NM_207111.3) - SHH397176 from Creative biogene Category siRNA Species Reactivities Human

Human RNF216 siRNA - orb270584 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RNF216 shRNA Plasmid (Human) - CHJ0083 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RNF216 miRNA 3'UTR clone - MiUTR4H-TG07605 from Creative biogene Species Reactivities Human

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