EBI3

Gene Symbol EBI3
Entrez Gene 10148
Alt Symbol IL-27B, IL27B
Species Human
Gene Type protein-coding
Description Epstein-Barr virus induced 3
Other Description EBV-induced gene 3 protein|Epstein-Barr virus induced gene 3|IL-27 subunit beta|IL27 subunit|IL35 subunit|cytokine receptor|epstein-Barr virus-induced gene 3 protein|interleukin-27 subunit beta
Swissprots O75269 A0N0N2 Q14213
Accessions AAC33488 ABK41923 CBX32665 CBX32666 EAW69244 EAW69245 Q14213 BC015364 AAH15364 BC046112 AAH46112 DQ891589 ABM82515 EU176581 ABW03382 L08187 AAA93193 XM_011527619 XP_011525921 NM_005755 NP_005746
Function Associates with IL27 to form the IL-27 interleukin, a heterodimeric cytokine which functions in innate immunity. IL-27 has pro- and anti-inflammatory properties, that can regulate T- helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL-27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines. {ECO:0000269|PubMed:12121660}.
Subcellular Location Secreted.

EBI3-Over-expression-Lysate - LY13135a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag EBI3 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the EBI3 gene

EBI3 overexpression lysate - LY417095 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

IL-27/IL-35 EBI3 Subunit Overexpression Lysate (Native) - NBP2-07710 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: EBI3 Overexpression Lysate (Adult Normal) [NBP2-07710] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EBI3.

Panoply™ Human EBI3 Knockdown Stable Cell Line - CSC-DC004682 from Creative biogene

Category Cell Line
Species Human
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