BATF

Gene Symbol	BATF
Entrez Gene	10538
Alt Symbol	B-ATF, BATF1, SFA-2, SFA2
Species	Human
Gene Type	protein-coding
Description	basic leucine zipper transcription factor, ATF-like
Other Description	B-cell-activating transcription factor|SF-HT-activated gene 2 protein|activating transcription factor B|basic leucine zipper transcriptional factor ATF-like
Swissprots	Q16520
Accessions	AAC78243 AAD51372 EAW81234 Q16520 BC032294 AAH32294 BP235761 D42106 BAA07686 U15460 AAC50314 NM_006399 NP_006390
Function	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune- specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.
Tissue Specificity	Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209). {ECO:0000269|PubMed:10777209, ECO:0000269|PubMed:8570175, ECO:0000269|PubMed:8630063}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BATF (D7C5) Rabbit mAb - 8638 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D7C5

B-ATF (H-19) - sc-15280 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

B-ATF (H-45) - sc-292654 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

B-ATF (WW8) - sc-100974 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

p-B-ATF (Thr 48) - sc-30444 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-BATF antibody - ab196762 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BATF antibody - ab129644 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BATF antibody - ab56683 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BATF antibody - ab56685 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BATF Antibody (aa105-119) - LS-C186446 from LifeSpan Bioscience Prices $335.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-BATF Antibody (aa10-59) - LS-C119079 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, AP) - LS-C252392 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (N-Terminus) - LS-C80233 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, APC) - LS-C252393 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa35-84) - LS-C101409 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, Biotin) - LS-C252394 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, PE) - LS-C252397 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, Azide-free, HRP) - LS-C252396 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35, FITC) - LS-C252395 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody - LS-C306499 from LifeSpan Bioscience Prices $455.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-BATF Antibody (aa34-125) - LS-C306503 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-BATF Antibody - LS-C309585 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa6-35) - LS-C319782 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (aa7-35) - LS-C156750 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-BATF Antibody (N-Terminus) - LS-C153723 from LifeSpan Bioscience Prices $345.00, $1,035.00 Sizes 100 µg, 500 µg Host Rabbit Clonality Polyclonal

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