BATF

Gene Symbol	BATF
Entrez Gene	10538
Alt Symbol	B-ATF, BATF1, SFA-2, SFA2
Species	Human
Gene Type	protein-coding
Description	basic leucine zipper transcription factor, ATF-like
Other Description	B-cell-activating transcription factor|SF-HT-activated gene 2 protein|activating transcription factor B|basic leucine zipper transcriptional factor ATF-like
Swissprots	Q16520
Accessions	AAC78243 AAD51372 EAW81234 Q16520 BC032294 AAH32294 BP235761 D42106 BAA07686 U15460 AAC50314 NM_006399 NP_006390
Function	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune- specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.
Tissue Specificity	Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209). {ECO:0000269|PubMed:10777209, ECO:0000269|PubMed:8570175, ECO:0000269|PubMed:8630063}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

BATF (Human) IP-WB Antibody Pair - H00010538-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

BATF (Human) Matched Antibody Pair - H00010538-AP21 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human BATF ELISA Kit - HB0645 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine BATF ELISA Kit - AB0645 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Basic leucine zipper transcription factor ATF like, ELISA Kit - MBS729096 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS723457 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS034565 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS755480 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS052516 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS720676 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 pg/mL.

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS747046 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS754225 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS033591 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS021835 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS727377 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS026712 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS047448 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS753504 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS006777 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS096637 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS070017 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS017797 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS722060 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic Leucine Zipper Transcription Factor Atf-Like, ELISA Kit - MBS042133 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Basic leucine zipper transcription factor ATF-like, ELISA Kit - MBS754859 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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