BATF

Gene Symbol	BATF
Entrez Gene	10538
Alt Symbol	B-ATF, BATF1, SFA-2, SFA2
Species	Human
Gene Type	protein-coding
Description	basic leucine zipper transcription factor, ATF-like
Other Description	B-cell-activating transcription factor|SF-HT-activated gene 2 protein|activating transcription factor B|basic leucine zipper transcriptional factor ATF-like
Swissprots	Q16520
Accessions	AAC78243 AAD51372 EAW81234 Q16520 BC032294 AAH32294 BP235761 D42106 BAA07686 U15460 AAC50314 NM_006399 NP_006390
Function	AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells (Th17), follicular T-helper cells (TfH), CD8(+) dendritic cells and class-switch recombination (CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4 (or IRF8) in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune- specific regulatory element, followed by cooperative binding of BATF and IRF4 (or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17 (Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17 (IL17A or IL17B). Also involved in differentiation of follicular T-helper cells (TfH) by directing expression
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. Cytoplasm {ECO:0000250}. Note=Present in the nucleus and cytoplasm, but shows increased nuclear translocation after activation of T-cells. {ECO:0000250}.
Tissue Specificity	Expressed at highest levels in lung, and at lower levels in placenta, liver, kidney, spleen, and peripheral blood. Detected in SW480 colorectal cancer cell line and several hematopoietic tumor cell lines, including Raji Burkitt's lymphoma. Strongly expressed in mature B- and T-lymphocytes. Also expressed in moderate levels in lymph node and appendix and at low levels in thymus and bone marrow (PubMed:10777209). {ECO:0000269|PubMed:10777209, ECO:0000269|PubMed:8570175, ECO:0000269|PubMed:8630063}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human BATF full length protein - ab104928 from Abcam Category Protein Prices $235.00, $866.00 Sizes 100 µg, 500 µg Source E. coli Species Human

BATF Antibody Blocking Peptide - LS-E4318 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BATF Antibody Blocking Peptide - LS-E31349 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BATF Antibody Blocking Peptide - LS-E13970 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BATF Antibody Blocking Peptide - LS-E28079 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BATF Recombinant Protein - H00010538-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

BATF Partial Recombinant Protein - H00010538-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human BATF Protein - NBP1-51006 from Novus Biologicals Category Protein Prices $269.00, $729.00 Sizes 100 µg, 500 µg Source E. coli Species Human

BATF-Antibody-N-term-Blocking-Peptide - BP16614a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BATF Protein (OPPA00071) - OPPA00071 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Escherichia Coli.

Human BATF protein - orb167953 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E. coli

BATF protein (His tag) - 80R-1687 from Fitzgerald Category Protein Prices $255.00 Sizes 100 µg Source E.coli

BATF Blocking Peptide - abx161297 from Abbexa Category Peptide Species Human, Rat

BATF Peptide - AC21-2958-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

BATF (1-125, His-tag) - AR09869PU-L from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

BATF (1-125, His-tag) - AR09869PU-N from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

BATF - H00010538-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

BATF - H00010538-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

BATF - H00010538-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BATF - H00010538-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BATF (N-term) Control Peptide - AP55462CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BATF, 1-125aa, Human, His tag, E.coli - 01-P0929 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

BATF Peptide - 7069P from ProSci Category Peptide Species Human

BATF fusion protein - ag4418 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

BATF Human - PRPS-126 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source Escherichia Coli. Species Human

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