| Gene Symbol |
SUMO4
|
| Entrez Gene |
387082
|
| Alt Symbol |
IDDM5, SMT3H4, SUMO-4, dJ281H8.4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small ubiquitin-like modifier 4
|
| Other Description |
SMT3 suppressor of mif two 3 homolog 2|SMT3 suppressor of mif two 3 homolog 4|insulin-dependent diabetes mellitus 5|small ubiquitin-like modifier 4 protein|small ubiquitin-related modifier 4
|
| Swissprots |
A1L3W5 Q6EEV6
|
| Accessions |
BAH05006 CAA20019 EAW47808 Q6EEV6 AY340238 AAR04484 BC130305 AAI30306 HQ258040 ADR82794 NM_001002255 NP_001002255
|
| Function |
Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:16236267}.
|
| Tissue Specificity |
Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916}.
|
| Top Pathways |
RNA transport
|
