Gene Symbol | SUMO4 |
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Entrez Gene | 387082 |
Alt Symbol | IDDM5, SMT3H4, SUMO-4, dJ281H8.4 |
Species | Human |
Gene Type | protein-coding |
Description | small ubiquitin-like modifier 4 |
Other Description | SMT3 suppressor of mif two 3 homolog 2|SMT3 suppressor of mif two 3 homolog 4|insulin-dependent diabetes mellitus 5|small ubiquitin-like modifier 4 protein|small ubiquitin-related modifier 4 |
Swissprots | A1L3W5 Q6EEV6 |
Accessions | BAH05006 CAA20019 EAW47808 Q6EEV6 AY340238 AAR04484 BC130305 AAI30306 HQ258040 ADR82794 NM_001002255 NP_001002255 |
Function | Ubiquitin-like protein which can be covalently attached to target lysines as a monomer. Does not seem to be involved in protein degradation and may modulate protein subcellular localization, stability or activity. Upon oxidative stress, conjugates to various anti-oxidant enzymes, chaperones, and stress defense proteins. May also conjugate to NFKBIA, TFAP2A and FOS, negatively regulating their transcriptional activity, and to NR3C1, positively regulating its transcriptional activity. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916, ECO:0000269|PubMed:16236267}. |
Tissue Specificity | Expressed mainly in adult and embryonic kidney. Expressed at various levels in immune tissues, with the highest expression in the lymph node and spleen. {ECO:0000269|PubMed:15123604, ECO:0000269|PubMed:15247916}. |
Top Pathways | RNA transport |
Human SUMO4 full length protein - ab157025 from Abcam
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SUMO4 protein (His-DHFR tag) - ab127386 from Abcam
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SUMO4 Antibody Blocking Peptide - LS-E1828 from LifeSpan Bioscience
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SUMO4 Antibody Blocking Peptide - LS-E1837 from LifeSpan Bioscience
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SUMO4 Antibody Blocking Peptide - LS-E1838 from LifeSpan Bioscience
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Recombinant Human SUMO4 Protein - H00387082-P01 from Novus Biologicals
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SUMO4 Peptide - P0326 from Novus Biologicals
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SUMO4-Antibody-V55-Mutant-Blocking-Peptide - BP1264b from Abgent, a WuXi AppTec company
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SUMO4-Antibody-M55-Wild-type-Blocking-Peptide - BP1264a from Abgent, a WuXi AppTec company
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SUMO4-Antibody-Center-Blocking-Peptide - BP1263b from Abgent, a WuXi AppTec company
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SUMO4 / SMT3H4 - H00387082-P01-10 from Acris Antibodies
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SUMO4 / SMT3H4 - H00387082-P01-25 from Acris Antibodies
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Recombinant Human Small ubiquitin-related modifier 4(SUMO4) - CSB-YP718803HU CSB-EP718803HU CSB-BP718803HU CSB-MP718803HU from Cusabio
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SUMO4 Protein - abx164409 from Abbexa
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SUMO4 Protein - NBP2-34073PEP from Novus Biologicals
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SUMO4-Antibody-N-term-Blocking-Peptide - BP1263a from Abgent, a WuXi AppTec company
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SUMO4-V55-MT-specific-Antibody-Blocking-Peptide - BP3729a from Abgent, a WuXi AppTec company
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SUMO4 Peptide, Human - M34GP15407H from Creative Peptides
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Adhiron scaffold protein anti-Human SUM04 - SAD-L256 from Creative Biolabs
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10-FnIII scaffold protein anti-Human SUMO4 - SFN-L008 from Creative Biolabs
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Human SUMO4 protein - orb54315 from Biorbyt
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SUMO4 Recombinant Protein (Human) (OPED00135) - OPED00135 from Aviva Systems Biology
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Small ubiquitin-related modifier 4 (SUMO4), Recombinant Protein - MBS1424429 from MyBioSource
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SUMO4 Recombinant Protein (Human) (OPCA04802) - OPCA04802 from Aviva Systems Biology
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Recombinant Human Small ubiquitin-related modifier 4 (SUMO4) - RPC23154 from Biomatik
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