SHB

Gene Symbol SHB
Entrez Gene 6461
Alt Symbol bA3J10.2
Species Human
Gene Type protein-coding
Description Src homology 2 domain containing adaptor protein B
Other Description SH2 domain-containing adapter protein B|SHB (Src homology 2 domain containing) adaptor protein B|SHB adaptor protein (a Src homology 2 protein)
Swissprots Q15464 Q504U5 B9EGM0 D3DRQ5 Q5VUM8
Accessions EAW58254 EAW58255 Q15464 AK055947 AK096227 BC029953 BC136581 AAI36582 BC136582 AAI36583 X75342 CAA53091 NM_003028 NP_003019
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9484780}.

Shb/Shf (B-1) - sc-74483 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Shb/Shf (B-1): sc-74483. Western blot analysis of Shb and Shf expression in K-562 (A) and KNRK (B) whole cell lysates.

Shb/Shf (C-20) - sc-530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Shb/Shf (C-20): sc-530. Western blot analysis of Shb/Shf expression in K-562 whole cell lysate.

Shb/Shf (H-130) - sc-28832 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-SHB (phospho Y246) antibody - ab138388 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-SHB (phospho Y246) antibody (ab138388) at 1/500 dilution + 293 cell lysate at 30 µg

Anti-SHB antibody - ab80239 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab80239, at a 1/10 dilution, staining SHB in formalin fixed, paraffin embedded human lung carcinoma tissue by Immunohistochemistry. A peroxidase conjugated secondary antibody was used, followed by DAB staining.

Anti-SHB antibody [EPR7976] - ab129190 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7976
All lanes : Anti-SHB antibody [EPR7976] (ab129190) at 1/1000 dilutionLane 1 : HepG2 cell lysatesLane 2 : K562 cell lysatesLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SHB antibody - C-terminal - ab175553 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-SHB antibody - C-terminal (ab175553) at 1/1000 dilution + 293 cell line lysates at 35 µg

Anti-SHB Antibody (aa496-509) - LS-C132077 from LifeSpan Bioscience

Prices $530.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-SHB Antibody (aa68-95, AP) - LS-C269317 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa68-95, Biotin) - LS-C269319 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa68-95, FITC) - LS-C269320 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa68-95, Azide-free, HRP) - LS-C269321 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa398-447) - LS-C200667 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from HUVEC cells using SHB antibody.

Anti-SHB Antibody (aa68-95, PE) - LS-C269322 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (phospho-Tyr246) - LS-C291523 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (Internal, clone EPR7976) - LS-C152584 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR7976
Western blot analysis on (A) HepG2 and (B) K562 cell lysates using anti-SHB antibody.

Anti-SHB Antibody (aa248-484, Biotin) - LS-C300703 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa252-507, Biotin) - LS-C300701 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (Val240) - LS-C177416 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Shb (V240) pAb in extracts from Jurkat cells.

Anti-SHB Antibody (aa248-484, FITC) - LS-C302114 from LifeSpan Bioscience

Prices $495.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (phospho-Tyr246) - LS-C178063 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of p-Shb (Y246) pAb in extracts from 293 cells.

Anti-SHB Antibody (aa252-507, FITC) - LS-C302112 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa35-84) - LS-C112249 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SHB antibody LS-C112249 Western blot of HepG2 cell lysate.

Anti-SHB Antibody (aa446-509) - LS-C311617 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SHB Antibody (aa67-95) - LS-C325091 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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