SHB

Gene Symbol	SHB
Entrez Gene	6461
Alt Symbol	bA3J10.2
Species	Human
Gene Type	protein-coding
Description	Src homology 2 domain containing adaptor protein B
Other Description	SH2 domain-containing adapter protein B|SHB (Src homology 2 domain containing) adaptor protein B|SHB adaptor protein (a Src homology 2 protein)
Swissprots	Q15464 Q504U5 B9EGM0 D3DRQ5 Q5VUM8
Accessions	EAW58254 EAW58255 Q15464 AK055947 AK096227 BC029953 BC136581 AAI36582 BC136582 AAI36583 X75342 CAA53091 NM_003028 NP_003019
Function	Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity	Widely expressed. {ECO:0000269|PubMed:9484780}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SHB peptide - ab22790 from Abcam Category Peptide Species Human

SHB Antibody Blocking Peptide - LS-E6488 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHB Antibody Blocking Peptide - LS-E21502 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHB Antibody Blocking Peptide - LS-E21501 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SHB Blocking Peptide - 33R-2710 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SHB Blocking Peptide - 33R-5681 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human SHB Protein - abx069163 from Abbexa Category Protein Source E.coli Species Human

SHB Blocking Peptide - abx063260 from Abbexa Category Peptide Species Human, Mouse, Rat

Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) - RPM223Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Src Homology 2 Domain Containing Adapter Protein B (SHB) - RPM223Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

SHB (pY246) Blocking Peptide - CBP2066 from Cohesion Biosciences Category Peptide Prices $150.00, $450.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Shb (V240) Peptide - BS3215P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

p-Shb (Y246) Peptide - BS4821P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human SH2 domain-containing adapter protein B(SHB) - CSB-YP618007HU CSB-EP618007HU CSB-BP618007HU CSB-MP618007HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SHB (full length, N-term HIS tag) - TP760831 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

SHB Recombinant Protein Antigen - NBP2-30557PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SHB-Antibody-N-term-Blocking-Peptide - BP1408a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SHB-Antibody-Center-Blocking-Peptide - BP1408c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HUMAN-SHBY268-Blocking-Peptide - BP20620a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg Species Human

SHB Peptide, Human - M34GP14195H from Creative Peptides Category Peptide Source Synthetic. Species Human

SHB Recombinant Protein (OPCD06948) - OPCD06948 from Aviva Systems Biology Category Protein Source E.coli Species Human

SH2 domain-containing adapter protein B (SHB), Recombinant Protein - MBS1306391 from MyBioSource Category Protein Prices $1,300.00, $1,300.00, $1,515.00, $1,515.00, $2,135.00, $2,135.00, $2,600.00, $2,600.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Src Homology 2 Domain Containing Adapter Protein B (SHB), Recombinant Protein - MBS2018451 from MyBioSource Category Protein Prices $190.00, $395.00, $610.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Human

SHB Recombinant Protein Antigen - NBP2-58223PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

SHB (phospho-Y246) peptide - orb217929 from Biorbyt Category Peptide

Search more