SHB

Gene Symbol SHB
Entrez Gene 6461
Alt Symbol bA3J10.2
Species Human
Gene Type protein-coding
Description Src homology 2 domain containing adaptor protein B
Other Description SH2 domain-containing adapter protein B|SHB (Src homology 2 domain containing) adaptor protein B|SHB adaptor protein (a Src homology 2 protein)
Swissprots Q15464 Q504U5 B9EGM0 D3DRQ5 Q5VUM8
Accessions EAW58254 EAW58255 Q15464 AK055947 AK096227 BC029953 BC136581 AAI36582 BC136582 AAI36583 X75342 CAA53091 NM_003028 NP_003019
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9484780}.

Shb CRISPR/Cas9 KO Plasmid (h) - sc-406120 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb HDR Plasmid (h) - sc-406120-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb Double Nickase Plasmid (h) - sc-406120-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb Double Nickase Plasmid (h2) - sc-406120-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb CRISPR Activation Plasmid (h) - sc-406120-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb CRISPR Activation Plasmid (h2) - sc-406120-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb Lentiviral Activation Particles (h) - sc-406120-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb Lentiviral Activation Particles (h2) - sc-406120-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Shb siRNA (h) - sc-40977 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shb shRNA Plasmid (h) - sc-40977-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Shb shRNA (h) Lentiviral Particles - sc-40977-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057881 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19288 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19288 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SHB siRNA (Human) - CRH4368 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHB - MBS8207993 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SHB (NM_003028.2) - SHH406944 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SHB(NM_003028.2) - SHR223998 from Creative biogene

Category siRNA
Species Reactivities Human

Human SHB siRNA - orb264870 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SHB shRNA Plasmid (Human) - CHH4368 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SHB miRNA 3'UTR clone - MiUTR1H-09373 from Creative biogene

Species Reactivities Human
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