SHB

Gene Symbol SHB
Entrez Gene 6461
Alt Symbol bA3J10.2
Species Human
Gene Type protein-coding
Description Src homology 2 domain containing adaptor protein B
Other Description SH2 domain-containing adapter protein B|SHB (Src homology 2 domain containing) adaptor protein B|SHB adaptor protein (a Src homology 2 protein)
Swissprots Q15464 Q504U5 B9EGM0 D3DRQ5 Q5VUM8
Accessions EAW58254 EAW58255 Q15464 AK055947 AK096227 BC029953 BC136581 AAI36582 BC136582 AAI36583 X75342 CAA53091 NM_003028 NP_003019
Function Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. {ECO:0000269|PubMed:10828022, ECO:0000269|PubMed:10837138, ECO:0000269|PubMed:12084069, ECO:0000269|PubMed:12464388, ECO:0000269|PubMed:12520086, ECO:0000269|PubMed:15026417, ECO:0000269|PubMed:15919073, ECO:0000269|PubMed:8806685, ECO:0000269|PubMed:9484780, ECO:0000269|PubMed:9751119}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Note=Associates with membrane lipid rafts upon TCR stimulation.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:9484780}.

SHB overexpression lysate - LY418949 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

SHB Overexpression Lysate (Native) - NBP2-08047 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: SHB Overexpression Lysate (Adult Normal) [NBP2-08047] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SHB.

Panoply™ Human SHB Knockdown Stable Cell Line - CSC-DC014195 from Creative biogene

Category Cell Line
Species Human
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