| Gene Symbol |
CYP27A1
|
| Entrez Gene |
1593
|
| Alt Symbol |
CP27, CTX, CYP27
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 27, subfamily A, polypeptide 1
|
| Other Description |
5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase|5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase|5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase|cholestanetriol 26-monooxygenase|cytochrome P-450C27/25|cytochrome P450 27|cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1|sterol 26-hydroxylase, mitochondrial|sterol 27-hydroxylase|vitamin D(3) 25-hydroxylase
|
| Swissprots |
Q02318 A8K303 Q86YQ6 Q6LDB4
|
| Accessions |
AAB27199 AAK51672 EAW70653 EAW70654 EAW70655 Q02318 AK226039 AK290418 BAF83107 AK310782 AY178622 AAO21126 BC017044 BC040430 AAH40430 BC051851 AAH51851 M62401 AAA52142 X59812 CAA42481 NM_000784 NP_000775
|
| Function |
Catalyzes the first step in the oxidation of the side chain of sterol intermediates; the 27-hydroxylation of 5-beta- cholestane-3-alpha,7-alpha,12-alpha-triol. Has also a vitamin D3- 25-hydroxylase activity.
|
| Subcellular Location |
Mitochondrion membrane.
|
| Top Pathways |
Primary bile acid biosynthesis, PPAR signaling pathway
|