NR2C1

Gene Symbol NR2C1
Entrez Gene 7181
Alt Symbol TR2
Species Human
Gene Type protein-coding
Description nuclear receptor subfamily 2, group C, member 1
Other Description TR2 nuclear hormone receptor|nuclear receptor subfamily 2 group C member 1|nuclear receptor subfamily 2, group C isoform|orphan nuclear receptor TR2
Swissprots Q15625 P13056 Q15626 A8K5K4
Accessions EAW97517 EAW97518 EAW97519 EAW97520 P13056 AB307707 BAH02298 AK291319 BAF84008 BC026074 BC040141 AAH40141 BE676699 DB266298 JF432345 ADZ15562 JQ308177 AFF59487 JQ308178 AFF59488 M21985 AAA36650 M29959 AAA36762 M29960 AAA36761 XM_005269133 XP_005269190 XM_006719584 XP_006719647 XM_006719585 XP_006719648 XM_006719586 XP_006719649 XM_011538716 XP_011537018 XM_011538717 XP_011537019 XR_245956 XR_429114 XR_944699 XR_944700 NM_001032287 NP_001027458 NM_001127362 NP_001120834 NM_003297 NP_003288
Function Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.

TR2 (G-11) - sc-365729 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TR2 (G-11): sc-365729. Western blot analysis of TR2 expression in NIH/3T3 whole cell lysate.

TR2 (D-4) - sc-374049 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TR2 (D-4): sc-374049. Western blot analysis of TR2 expression in HeLa whole cell lysate.

TR2 (N-19) - sc-8617 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TR2 (N-19): sc-8617. Western blot analysis of TR2 expression in non-transfected: sc-117752 (A) and human TR2 transfected: sc-115542 (B) 293T whole cell lysates.

TR2 (M-85) - sc-9087 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TR2 (M-85): sc-9087. Immunoperoxidase staining of formalin fixed, paraffin-embedded human testis tissue showing nuclear and cytoplasmic staining of cells in ductus seminiferus at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

TR2 (C-19) - sc-8618 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TR2-11 antibody - ab83101 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-TR2-11 antibody (ab83101) at 1 µg/ml + Jurkat cell lysate at 10 µgSecondary HRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-TR2-11 antibody - ab155295 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-TR2-11 antibody (ab155295) at 1/1000 dilutionLane 1 : 293T whole cell lysateLane 2 : A431 whole cell lysateLane 3 : HeLa whole cell lysateLane 4 : HepG2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-TR2-11 antibody - ab37433 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-TR2-11 antibody [449C1a] - ab58648 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 449C1a
Anti-TR2-11 antibody [449C1a] (ab58648) + immunising recombinant fragment

Anti-TR2-11 antibody [4E4] - ab180531 from Abcam

Prices $357.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4E4
All lanes : Anti-TR2-11 antibody [4E4] (ab180531) at 1/2000 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY TR2-11Lysates/proteins at 5 µg per lane.

Anti-NR2C1 Antibody (aa432-481) - LS-C102851 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR2C1 / TR2-11 antibody LS-C102851 Western blot of Jurkat lysate.

Anti-NR2C1 Antibody (aa516-545, APC) - LS-C264707 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa516-545, FITC) - LS-C264710 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa516-545, Biotin) - LS-C264709 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody - LS-C109418 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate). A: A431. B: H1299. 10% SDS PAGE. NR2C1 antibody diluted at 1:1000

Anti-NR2C1 Antibody - LS-C195030 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot of NR2C1 antibody. Western blot of rat testes lysate showing specific immunolabeling of ~ 64k TR2 protein

Anti-NR2C1 Antibody (aa516-545, Azide-free, HRP) - LS-C264711 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (N-Terminus) - LS-C116058 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
NR2C1 / TR2-11 antibody LS-C116058 Western blot of Mouse Lung lysate.

Anti-NR2C1 Antibody (aa516-545, PE) - LS-C264712 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa1-50) - LS-C289750 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa553-603) - LS-C289754 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa51-100) - LS-C201333 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Mouse Stomach. Nr2c1 antibody dilution 1.0 ug/ml.

Anti-NR2C1 Antibody - LS-C150346 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa515-545) - LS-C323436 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NR2C1 Antibody (aa516-545) - LS-C162989 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
NR2C1 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The NR2C1 antibody detected the NR2C1 protein (arrow).
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