NR2C1
| Gene Symbol | NR2C1 |
|---|---|
| Entrez Gene | 7181 |
| Alt Symbol | TR2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nuclear receptor subfamily 2, group C, member 1 |
| Other Description | TR2 nuclear hormone receptor|nuclear receptor subfamily 2 group C member 1|nuclear receptor subfamily 2, group C isoform|orphan nuclear receptor TR2 |
| Swissprots | Q15625 P13056 Q15626 A8K5K4 |
| Accessions | EAW97517 EAW97518 EAW97519 EAW97520 P13056 AB307707 BAH02298 AK291319 BAF84008 BC026074 BC040141 AAH40141 BE676699 DB266298 JF432345 ADZ15562 JQ308177 AFF59487 JQ308178 AFF59488 M21985 AAA36650 M29959 AAA36762 M29960 AAA36761 XM_005269133 XP_005269190 XM_006719584 XP_006719647 XM_006719585 XP_006719648 XM_006719586 XP_006719649 XM_011538716 XP_011537018 XM_011538717 XP_011537019 XR_245956 XR_429114 XR_944699 XR_944700 NM_001032287 NP_001027458 NM_001127362 NP_001120834 NM_003297 NP_003288 |
| Function | Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}. |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}. |
TR2 CRISPR/Cas9 KO Plasmid (h) - sc-403818 from Santa Cruz Biotechnology
|
||||||||
TR2 HDR Plasmid (h) - sc-403818-HDR from Santa Cruz Biotechnology
|
||||||||
TR2 Double Nickase Plasmid (h) - sc-403818-NIC from Santa Cruz Biotechnology
|
||||||||
TR2 Double Nickase Plasmid (h2) - sc-403818-NIC-2 from Santa Cruz Biotechnology
|
||||||||
TR2 CRISPR Activation Plasmid (h) - sc-403818-ACT from Santa Cruz Biotechnology
|
||||||||
TR2 CRISPR Activation Plasmid (h2) - sc-403818-ACT-2 from Santa Cruz Biotechnology
|
||||||||
TR2 Lentiviral Activation Particles (h) - sc-403818-LAC from Santa Cruz Biotechnology
|
||||||||
TR2 Lentiviral Activation Particles (h2) - sc-403818-LAC-2 from Santa Cruz Biotechnology
|
||||||||
TR2 siRNA (h) - sc-38892 from Santa Cruz Biotechnology
|
||||||||
TR2 shRNA Plasmid (h) - sc-38892-SH from Santa Cruz Biotechnology
|
||||||||
TR2 shRNA (h) Lentiviral Particles - sc-38892-V from Santa Cruz Biotechnology
|
||||||||
TR2/NR2C1 RNAi - H00007181-R01 from Novus Biologicals
|
||||||||
TR2/NR2C1 RNAi - H00007181-R02 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU085651 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN15490 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15490 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03325 from Sigma-Aldrich
|
||||||||
NR2C1 siRNA (Human) - CRH4931 from Cohesion Biosciences
|
||||||||
shRNA set against Human NR2C1 (NM_003297.3) - SHH354724 from Creative biogene
|
||||||||
NR2C1 shRNA Plasmid (Human) - CHH4931 from Cohesion Biosciences
|
||||||||
NR2C1 miRNA 3'UTR clone - MiUTR3H-04187 from Creative biogene
|
||||||||
NR2C1 miRNA 3'UTR clone - MiUTR3H-04188 from Creative biogene
|
||||||||
NR2C1 miRNA 3'UTR clone - MiUTR3H-04189 from Creative biogene
|