| Gene Symbol |
NR2C1
|
| Entrez Gene |
7181
|
| Alt Symbol |
TR2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 2, group C, member 1
|
| Other Description |
TR2 nuclear hormone receptor|nuclear receptor subfamily 2 group C member 1|nuclear receptor subfamily 2, group C isoform|orphan nuclear receptor TR2
|
| Swissprots |
Q15625 P13056 Q15626 A8K5K4
|
| Accessions |
EAW97517 EAW97518 EAW97519 EAW97520 P13056 AB307707 BAH02298 AK291319 BAF84008 BC026074 BC040141 AAH40141 BE676699 DB266298 JF432345 ADZ15562 JQ308177 AFF59487 JQ308178 AFF59488 M21985 AAA36650 M29959 AAA36762 M29960 AAA36761 XM_005269133 XP_005269190 XM_006719584 XP_006719647 XM_006719585 XP_006719648 XM_006719586 XP_006719649 XM_011538716 XP_011537018 XM_011538717 XP_011537019 XR_245956 XR_429114 XR_944699 XR_944700 NM_001032287 NP_001027458 NM_001127362 NP_001120834 NM_003297 NP_003288
|
| Function |
Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation. {ECO:0000269|PubMed:12093804, ECO:0000269|PubMed:17010934}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}. Nucleus, PML body {ECO:0000250}. Note=Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation. {ECO:0000250}.
|