| Gene Symbol | MR1 |
|---|---|
| Entrez Gene | 3140 |
| Alt Symbol | HLALS |
| Species | Human |
| Gene Type | protein-coding |
| Description | major histocompatibility complex, class I-related |
| Other Description | MHC class I-like antigen MR-1|MHC class I-related gene protein|MHC class-I related-gene protein|class I histocompatibility antigen-like protein|major histocompatibility complex class I-related gene protein|major histocompatibility complex, class I-like sequence |
| Swissprots | Q9TQB3 O97986 O97985 Q95HB8 Q95460 Q9MY23 Q9TQB9 Q9TQK3 B4E3B1 Q53GM1 A8K2V9 Q9NPL2 |
| Accessions | AAD02172 AAF40170 EAW91095 EAW91096 EAW91097 EAW91098 Q95460 AF010446 AAD01442 AF010447 AAD01443 AF031469 AAD01933 AJ249778 CAB77667 AK056155 AK222910 BAD96630 AK290374 BAF83063 AK304645 BAG65423 BC012485 AAH12485 DC297418 U22963 AAC50174 XM_006711286 XP_006711349 XM_011509462 XP_011507764 XM_011509463 XP_011507765 NM_001194999 NP_001181928 NM_001195000 NP_001181929 NM_001195035 NP_001181964 NM_001531 NP_001522 |
| Function | Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:19416870}. |
| Subcellular Location | Isoform 3: Cell membrane {ECO:0000269|PubMed:23457030}; Single-pass type I membrane protein {ECO:0000269|PubMed:23457030}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030}. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway. |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:7624800}. |