MR1

Gene Symbol MR1
Entrez Gene 3140
Alt Symbol HLALS
Species Human
Gene Type protein-coding
Description major histocompatibility complex, class I-related
Other Description MHC class I-like antigen MR-1|MHC class I-related gene protein|MHC class-I related-gene protein|class I histocompatibility antigen-like protein|major histocompatibility complex class I-related gene protein|major histocompatibility complex, class I-like sequence
Swissprots Q9TQB3 O97986 O97985 Q95HB8 Q95460 Q9MY23 Q9TQB9 Q9TQK3 B4E3B1 Q53GM1 A8K2V9 Q9NPL2
Accessions AAD02172 AAF40170 EAW91095 EAW91096 EAW91097 EAW91098 Q95460 AF010446 AAD01442 AF010447 AAD01443 AF031469 AAD01933 AJ249778 CAB77667 AK056155 AK222910 BAD96630 AK290374 BAF83063 AK304645 BAG65423 BC012485 AAH12485 DC297418 U22963 AAC50174 XM_006711286 XP_006711349 XM_011509462 XP_011507764 XM_011509463 XP_011507765 NM_001194999 NP_001181928 NM_001195000 NP_001181929 NM_001195035 NP_001181964 NM_001531 NP_001522
Function Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T- cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. {ECO:0000269|PubMed:12794138, ECO:0000269|PubMed:19416870}.
Subcellular Location Isoform 3: Cell membrane {ECO:0000269|PubMed:23457030}; Single-pass type I membrane protein {ECO:0000269|PubMed:23457030}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:23457030}. Note=The larger proportion remains in the ER in an immature state. The subset that reach cell surface does it through a B2M-independent pathway.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:7624800}.

MR1 CRISPR/Cas9 KO Plasmid (h) - sc-417241 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 HDR Plasmid (h) - sc-417241-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 Double Nickase Plasmid (h) - sc-417241-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 Double Nickase Plasmid (h2) - sc-417241-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 CRISPR Activation Plasmid (h) - sc-417241-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 CRISPR Activation Plasmid (h2) - sc-417241-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 Lentiviral Activation Particles (h) - sc-417241-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 Lentiviral Activation Particles (h2) - sc-417241-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MR1 siRNA (h) - sc-88089 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MR1 shRNA Plasmid (h) - sc-88089-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MR1 shRNA (h) Lentiviral Particles - sc-88089-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MR1 RNAi - H00003140-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN14521 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14521 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01404 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01404

MR1 siRNA (Human) - CRH2143 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human MR1 siRNA - orb262645 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MR1 shRNA Plasmid (Human) - CHH2143 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MR1 miRNA 3'UTR clone - MiUTR3H-03615 from Creative biogene

Species Reactivities Human
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