PTBP1
| Gene Symbol | PTBP1 |
|---|---|
| Entrez Gene | 5725 |
| Alt Symbol | HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB |
| Species | Human |
| Gene Type | protein-coding |
| Description | polypyrimidine tract binding protein 1 |
| Other Description | 57 kDa RNA-binding protein PPTB-1|RNA-binding protein|heterogeneous nuclear ribonucleoprotein I|heterogeneous nuclear ribonucleoprotein polypeptide I|hnRNP I|polypyrimidine tract binding protein (heterogeneous nuclear ribonucleoprotein I)|polypyrimidine tract-binding protein 1 |
| Swissprots | Q9BUQ0 P26599 |
| Accessions | AAC99798 EAW61152 EAW61153 EAW61154 EAW61155 EAW61156 EAW61157 EAW61158 P26599 AB208910 BAD92147 BC002397 AAH02397 BC004383 AAH04383 BC013694 AAH13694 BC023219 BQ068293 BT006819 AAP35465 X60648 CAA43056 X62006 CAA43973 X65371 CAA46443 X65372 CAA46444 X66975 CAA47386 XM_005259597 XP_005259654 XM_005259598 XP_005259655 XR_244034 XR_244035 NM_002819 NP_002810 NM_031990 NP_114367 NM_031991 NP_114368 NM_175847 |
| Function | Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:11003644, ECO:0000269|PubMed:15009664, ECO:0000269|PubMed:16179478, ECO:0000269|PubMed:16260624, ECO:0000269|PubMed:21518792}. |
| Subcellular Location | Nucleus. |
hnRNP I CRISPR/Cas9 KO Plasmid (h) - sc-401435 from Santa Cruz Biotechnology
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hnRNP I HDR Plasmid (h) - sc-401435-HDR from Santa Cruz Biotechnology
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hnRNP I Double Nickase Plasmid (h) - sc-401435-NIC from Santa Cruz Biotechnology
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hnRNP I Double Nickase Plasmid (h2) - sc-401435-NIC-2 from Santa Cruz Biotechnology
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hnRNP I CRISPR Activation Plasmid (h) - sc-401435-ACT from Santa Cruz Biotechnology
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hnRNP I CRISPR Activation Plasmid (h2) - sc-401435-ACT-2 from Santa Cruz Biotechnology
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hnRNP I Lentiviral Activation Particles (h) - sc-401435-LAC from Santa Cruz Biotechnology
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hnRNP I Lentiviral Activation Particles (h2) - sc-401435-LAC-2 from Santa Cruz Biotechnology
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hnRNP I siRNA (h) - sc-38280 from Santa Cruz Biotechnology
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hnRNP I shRNA Plasmid (h) - sc-38280-SH from Santa Cruz Biotechnology
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hnRNP I shRNA (h) Lentiviral Particles - sc-38280-V from Santa Cruz Biotechnology
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PTBP1 RNAi - H00005725-R03 from Novus Biologicals
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PTBP1 RNAi - H00005725-R01 from Novus Biologicals
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PTBP1 RNAi - H00005725-R04 from Novus Biologicals
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MISSION® esiRNA - EHU088121 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1059 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1059 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09295 from Sigma-Aldrich
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PTBP1 siRNA (Human) - CRH3869 from Cohesion Biosciences
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PTBP1 RNAi - H00005725-R02 from Novus Biologicals
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hnRNP I CRISPR/Cas9 KO Plasmid (h2) - sc-401435-KO-2 from Santa Cruz Biotechnology
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hnRNP I HDR Plasmid (h2) - sc-401435-HDR-2 from Santa Cruz Biotechnology
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Human PTBP1 siRNA - orb264371 from Biorbyt
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PTBP1 shRNA Plasmid (Human) - CHH3869 from Cohesion Biosciences
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PTBP1 miRNA 3'UTR clone - MiUTR3H-03560 from Creative biogene
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