| Gene Symbol |
NDST4
|
| Entrez Gene |
64579
|
| Alt Symbol |
NDST-4, NHSST4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4
|
| Other Description |
N-HSST 4|N-heparan sulfate sulfotransferase 4|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4|glucosaminyl N-deacetylase/N-sulfotransferase 4
|
| Swissprots |
Q9H3R1 Q2KHM8
|
| Accessions |
EAX06309 Q9H3R1 AB036429 BAB18535 AK289670 BAF82359 BC012326 BC113075 AAI13076 BC156696 AAI56697 NM_022569 NP_072091
|
| Function |
Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - heparan sulfate / heparin
|
