Gene Symbol | NDST4 |
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Entrez Gene | 64579 |
Alt Symbol | NDST-4, NHSST4 |
Species | Human |
Gene Type | protein-coding |
Description | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Other Description | N-HSST 4|N-heparan sulfate sulfotransferase 4|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4|glucosaminyl N-deacetylase/N-sulfotransferase 4 |
Swissprots | Q9H3R1 Q2KHM8 |
Accessions | EAX06309 Q9H3R1 AB036429 BAB18535 AK289670 BAF82359 BC012326 BC113075 AAI13076 BC156696 AAI56697 NM_022569 NP_072091 |
Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
NDST4 (F-20) - sc-16772 from Santa Cruz Biotechnology
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NDST4 (I-18) - sc-16771 from Santa Cruz Biotechnology
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Anti-NDST4 antibody - ab68726 from Abcam
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Anti-NDST4 antibody - ab98060 from Abcam
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Anti-NDST4 antibody - N-terminal - ab173809 from Abcam
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Anti-NDST4 Antibody (aa185-212, AP) - LS-C237927 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212, APC) - LS-C237928 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212, Biotin) - LS-C237930 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212, FITC) - LS-C237931 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212, PE) - LS-C237933 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa184-212) - LS-C323265 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212, Azide-free, HRP) - LS-C248887 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa611-660) - LS-C107593 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa218-267) - LS-C81443 from LifeSpan Bioscience
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Anti-NDST4 Antibody (aa185-212) - LS-C158372 from LifeSpan Bioscience
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NDST4 Antibody - NBP1-62254 from Novus Biologicals
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NDST4 Antibody - NBP1-62410 from Novus Biologicals
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NDST4 Antibody - NBP1-86481 from Novus Biologicals
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NDST4 Antibody - H00064579-D01P from Novus Biologicals
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NDST4 Antibody - H00064579-B01P from Novus Biologicals
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NDST4 Antibody - H00064579-A01 from Novus Biologicals
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Anti-NDST4 antibody produced in rabbit - SAB2104885 from Sigma-Aldrich
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Anti-NDST4 antibody produced in rabbit - HPA011129 from Sigma-Aldrich
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Anti-NDST4 antibody produced in rabbit - SAB2101560 from Sigma-Aldrich
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Anti-NDST4 antibody produced in rabbit - SAB1411268 from Sigma-Aldrich
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