Gene Symbol | NDST4 |
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Entrez Gene | 64579 |
Alt Symbol | NDST-4, NHSST4 |
Species | Human |
Gene Type | protein-coding |
Description | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Other Description | N-HSST 4|N-heparan sulfate sulfotransferase 4|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4|glucosaminyl N-deacetylase/N-sulfotransferase 4 |
Swissprots | Q9H3R1 Q2KHM8 |
Accessions | EAX06309 Q9H3R1 AB036429 BAB18535 AK289670 BAF82359 BC012326 BC113075 AAI13076 BC156696 AAI56697 NM_022569 NP_072091 |
Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
Human NDST4 full length protein - ab163847 from Abcam
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Human NDST4 protein fragment - ab163848 from Abcam
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NDST4 Antibody Blocking Peptide - LS-E5580 from LifeSpan Bioscience
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NDST4 Antibody Blocking Peptide - LS-E17955 from LifeSpan Bioscience
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Recombinant Human NDST4 Protein - H00064579-Q01 from Novus Biologicals
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NDST4 Recombinant Protein - H00064579-P01 from Novus Biologicals
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NDST4-Antibody-N-term-Blocking-Peptide - BP18104a from Abgent, a WuXi AppTec company
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NDST4 Blocking Peptide - 33R-2334 from Fitzgerald
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NDST4 Blocking Peptide - 33R-10167 from Fitzgerald
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NDST4 - H00064579-P01 from Acris Antibodies
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NDST4 - H00064579-Q01-10 from Acris Antibodies
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NDST4 - H00064579-Q01-25 from Acris Antibodies
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Recombinant Human Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase - CSB-YP862009HU CSB-EP862009HU CSB-BP862009HU CSB-MP862009HU from Cusabio
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NDST4 Recombinant Protein Antigen - NBP1-86481PEP from Novus Biologicals
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NDST4 Peptide, Human - M34GP10226H from Creative Peptides
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Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (NDST4), partial, Recombinant Protein - MBS1481561 from MyBioSource
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