Gene Symbol | NDST4 |
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Entrez Gene | 64579 |
Alt Symbol | NDST-4, NHSST4 |
Species | Human |
Gene Type | protein-coding |
Description | N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 4 |
Other Description | N-HSST 4|N-heparan sulfate sulfotransferase 4|bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4|glucosaminyl N-deacetylase/N-sulfotransferase 4 |
Swissprots | Q9H3R1 Q2KHM8 |
Accessions | EAX06309 Q9H3R1 AB036429 BAB18535 AK289670 BAF82359 BC012326 BC113075 AAI13076 BC156696 AAI56697 NM_022569 NP_072091 |
Function | Essential bifunctional enzyme that catalyzes both the N- deacetylation and the N-sulfation of glucosamine (GlcNAc) of the glycosaminoglycan in heparan sulfate. Modifies the GlcNAc-GlcA disaccharide repeating sugar backbone to make N-sulfated heparosan, a prerequisite substrate for later modifications in heparin biosynthesis. Has low deacetylase activity but high sulfotransferase activity (By similarity). {ECO:0000250}. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Top Pathways | Glycosaminoglycan biosynthesis - heparan sulfate / heparin |
NDST4 CRISPR/Cas9 KO Plasmid (h) - sc-413015 from Santa Cruz Biotechnology
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NDST4 HDR Plasmid (h) - sc-413015-HDR from Santa Cruz Biotechnology
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NDST4 Double Nickase Plasmid (h) - sc-413015-NIC from Santa Cruz Biotechnology
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NDST4 Double Nickase Plasmid (h2) - sc-413015-NIC-2 from Santa Cruz Biotechnology
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NDST4 CRISPR Activation Plasmid (h) - sc-413015-ACT from Santa Cruz Biotechnology
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NDST4 CRISPR Activation Plasmid (h2) - sc-413015-ACT-2 from Santa Cruz Biotechnology
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NDST4 Lentiviral Activation Particles (h) - sc-413015-LAC from Santa Cruz Biotechnology
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NDST4 Lentiviral Activation Particles (h2) - sc-413015-LAC-2 from Santa Cruz Biotechnology
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NDST4 siRNA (h) - sc-40767 from Santa Cruz Biotechnology
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NDST4 shRNA Plasmid (h) - sc-40767-SH from Santa Cruz Biotechnology
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NDST4 shRNA (h) Lentiviral Particles - sc-40767-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU051231 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15133 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15133 from Sigma-Aldrich
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NDST4 siRNA (Human) - CRJ2035 from Cohesion Biosciences
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NDST4 RNAi - H00064579-R01 from Novus Biologicals
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shRNA set against Human NDST4 (NM_022569.1) - SHH350448 from Creative biogene
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shRNA set against Human NDST4(NM_022569.1) - SHR004358 from Creative biogene
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NDST4 shRNA Plasmid (Human) - CHJ2035 from Cohesion Biosciences
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NDST4 miRNA 3'UTR clone - MiUTR1H-06694 from Creative biogene
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