SPIN1

Gene Symbol SPIN1
Entrez Gene 10927
Alt Symbol SPIN
Species Human
Gene Type protein-coding
Description spindlin 1
Other Description ovarian cancer-related protein|spindlin-1|spindlin1
Swissprots Q7KZJ8 B3KRQ4 A8K0X6 Q9Y657 Q9H0N7 Q9GZT2
Accessions EAW62753 EAW62754 EAW62755 Q9Y657 AF087864 AAG48367 AF106682 AAD43035 AF317228 AAG38112 AJ420427 AK024590 AK027044 AK092017 BAG52466 AK289691 BAF82380 AK290009 BAF82698 AK315854 BAF98745 AL136719 CAB66653 AM392778 CAL37656 AM393748 CAL38623 BC013571 BC114515 AAI14516 BC114565 AAI14566 BT007314 AAP35978 CR533484 CAG38515 DB465491 DQ893536 ABM84462 DQ896800 ABM87799 NM_006717 NP_006708
Function Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551}.
Subcellular Location Nucleus. Nucleus, nucleolus.
Tissue Specificity Highly expressed in ovarian cancer tissues. {ECO:0000269|PubMed:22258766}.

SPIN1 (N-14) - sc-160835 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPIN1 (N-14): sc-160835. Western blot analysis of SPIN1 expression in mouse embryo tissue extract.

SPIN1 (S-14) - sc-160836 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPIN1 (S-14): sc-160836. Western blot analysis of SPIN1 expression in NIH/3T3 nuclear extract.

Anti-spindlin 1 antibody - ab196938 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-spindlin 1 antibody (ab196938) at 1/500 dilutionLane 1 : MCF7 cell extractLane 2 : SW480 cell extractLane 3 : 293T cell extractLane 4 : Jurkat cell extractLane 5 : HeLa cell extractLane 6 : HepG2 cell extractLane 7 : SHSY5Y cell extractLane 8 : Mouse brain extract

Anti-spindlin 1 antibody - ab118784 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-spindlin 1 antibody (ab118784) at 1 µg/ml + Human fetal brain lysate at 10 µg

Anti-spindlin 1 antibody - ab138266 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-spindlin 1 antibody (ab138266) at 1/500 dilution + K562 cell lysate at 30 µg

Anti-SPIN / SPIN1 Antibody (His139) - LS-C192056 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPIN / SPIN1 Antibody (aa179-228) - LS-C116464 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
SPIN1 / SPIN antibody LS-C116464 Western blot of Fetal Brain lysate.

Anti-SPIN / SPIN1 Antibody (N-Terminus) - LS-C345498 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of SPIN1 Antibody with human Ovary Tumor lysate.

Anti-SPIN / SPIN1 Antibody (aa90-139) - LS-C200717 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from K562 cells using SPIN1 antibody.

Anti-SPIN / SPIN1 Antibody - LS-C334339 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence analysis of A549 cell using SPIN1 antibody. Blue: DAPI for nuclear staining.

Anti-SPIN / SPIN1 Antibody (aa111-160) IHC-plus™ - LS-B10006 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SPIN / SPIN1 antibody IHC staining of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10006 concentration 10 ug/ml.

SPIN1 Antibody - NBP1-55765 from Novus Biologicals

Prices $229.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western Blot: SPIN1 Antibody [NBP1-55765] - Analysis of extracts from HeLa cells, using SPIN1 Antibody. The lane on the right is treated with the synthesized peptide.

Spindlin 1 Polyclonal Antibody - bs-0724R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded mouse embryo labeled with Rabbit Anti Spindlin 1 Polyclonal Antibody, Unconjugated (bs-0724R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-SPIN1 (6-20) antibody produced in rabbit - SAB1101686 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-SPIN1 (6-20) (RB): <B>Cat. No. SAB1101686</B>: Immunofluorescence of HUVEC cells using Anti-SPIN1 (6-20) (RB) at a 1:50 dilution, taken at 40× magnification and nuclear staining with Hoescht 33342 (blue). Yale HTCB IF procedure used. Images may have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-SPIN1 antibody produced in rabbit - SAB4300736 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SPIN1 antibody produced in rabbit - SAB4500179 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-SPIN1: <B>Cat. No. SAB4500179</B>: Immunoblotting analysis of extracts from HeLa cells, using Anti-SPIN1 antibody. The lane on the left was treated with the Anti-SPIN1 antibody. The lane on the right (negative control) was treated with both Anti-SPIN1 antibody and the synthesized immunogen peptide.

SPIN1 Antibody - N-terminal region (ARP52247_P050) - ARP52247_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPIN1 antibody - middle region (ARP52248_P050) - ARP52248_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SPIN1 Antibody (OAAF02781) - OAAF02781 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SPIN1 Antibody (OAAF07163) - OAAF07163 from Aviva Systems Biology

Prices $289.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SPIN1 Polyclonal Antibody - A5853 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using SPIN1 antibody.

SPIN1 antibody - 70R-20494 from Fitzgerald

Host Rabbit
Clonality Polyclonal

SPIN1 Antibody - abx013873 from Abbexa

Host Rabbit
Clonality Polyclonal

SPIN1 Antibody - abx004490 from Abbexa

Host Rabbit
Clonality Polyclonal

Spindlin 1 / SPIN1 antibody - 12105-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Human brain were subjected to SDS PAGE followed by western blot with 12105-1-AP(SPIN1 Antibody) at dilution of 1:600
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