SPIN1

Gene Symbol	SPIN1
Entrez Gene	10927
Alt Symbol	SPIN
Species	Human
Gene Type	protein-coding
Description	spindlin 1
Other Description	ovarian cancer-related protein|spindlin-1|spindlin1
Swissprots	Q7KZJ8 B3KRQ4 A8K0X6 Q9Y657 Q9H0N7 Q9GZT2
Accessions	EAW62753 EAW62754 EAW62755 Q9Y657 AF087864 AAG48367 AF106682 AAD43035 AF317228 AAG38112 AJ420427 AK024590 AK027044 AK092017 BAG52466 AK289691 BAF82380 AK290009 BAF82698 AK315854 BAF98745 AL136719 CAB66653 AM392778 CAL37656 AM393748 CAL38623 BC013571 BC114515 AAI14516 BC114565 AAI14566 BT007314 AAP35978 CR533484 CAG38515 DB465491 DQ893536 ABM84462 DQ896800 ABM87799 NM_006717 NP_006708
Function	Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551}.
Subcellular Location	Nucleus. Nucleus, nucleolus.
Tissue Specificity	Highly expressed in ovarian cancer tissues. {ECO:0000269|PubMed:22258766}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human spindlin 1 full length protein - ab128446 from Abcam Category Protein Source E. coli Species Human

SPIN1 Recombinant Protein - H00010927-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human SPIN1 Protein - NBP1-98940 from Novus Biologicals Category Protein Prices $269.00 Sizes 20 µg Source E. coli Species Human

SPIN1-Antibody-N-term-Blocking-Peptide - BP8827a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human SPIN1 protein - orb169342 from Biorbyt Category Protein Prices $170.00, $289.00, $1,139.00 Sizes 1 μg, 5 μg, 50 μg Source E.coli

SPIN1 protein (His tag) - 80R-2329 from Fitzgerald Category Protein Prices $270.00 Sizes 20 µg Source E.coli

Spindlin 1 / SPIN1 (1-262, His-tag) - AR50413PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 100 µg Source E. coli Species Human

Spindlin 1 / SPIN1 (1-262, His-tag) - AR50413PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 20 µg Source E. coli Species Human

Spindlin 1 / SPIN1 - H00010927-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Spindlin 1 / SPIN1 - H00010927-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SPIN1, 1-262aa, Human, His tag, E.coli - 01-P1589 from ARP American Research Products Category Protein Prices $139.00, $369.00, $849.00 Sizes 5 µg, 20 µg, 100 µg Species Human

SPIN1 fusion protein - Ag2750 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SPIN1 Human - PRPS-1191 from NeoScientific Category Protein Prices $65.00, $169.00, $1,560.00 Sizes 1 µg, 5 µg, 50 µg Source E.coli. Species Human

Recombinant Human SPIN1 Protein - BP002250-PRO-1184 from Syd Labs Category Protein Prices $160.00, $1,200.00 Sizes 5 µg, 50 µg Source E. coli-derived. Species Human

SPIN1, 1-262aa, Recombinant Protein - GWB-P0449G from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 20 μg, 100 μg Source E.coli Species Human

Recombinant Human Spindlin 1, His-tagged - SPIN1-6839H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human SPIN1, GST-tagged - SPIN1-2916H from Creative Biomart Category Protein Source E.coli Species Human

Spindlin-1 (H139) Peptide - BS2678P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Spindlin-1(SPIN1) - CSB-YP897305HU CSB-EP897305HU CSB-BP897305HU CSB-MP897305HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SPIN1, 1-262aa, Human, His tag, E.coli - ATGP1589 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 4 µg, 20 µg, 100 µg Species Human

SPIN1 Blocking Peptide - abx161738 from Abbexa Category Peptide Species Human, Mouse, Rat, Chicken, Monkey, Pig

Spindlin-1 Protein (Recombinant) - abx263301 from Abbexa Category Protein

Recombinant Spindlin 1 (SPIN1) - RPC867Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Spindlin 1 / SPIN1 - TP301938 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Spindlin 1 (SPIN1) - RPC867Hu01 from Cloud-clone Category Protein Source E.coli Species Human

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