| Gene Symbol |
SPIN1
|
| Entrez Gene |
10927
|
| Alt Symbol |
SPIN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindlin 1
|
| Other Description |
ovarian cancer-related protein|spindlin-1|spindlin1
|
| Swissprots |
Q7KZJ8 B3KRQ4 A8K0X6 Q9Y657 Q9H0N7 Q9GZT2
|
| Accessions |
EAW62753 EAW62754 EAW62755 Q9Y657 AF087864 AAG48367 AF106682 AAD43035 AF317228 AAG38112 AJ420427 AK024590 AK027044 AK092017 BAG52466 AK289691 BAF82380 AK290009 BAF82698 AK315854 BAF98745 AL136719 CAB66653 AM392778 CAL37656 AM393748 CAL38623 BC013571 BC114515 AAI14516 BC114565 AAI14566 BT007314 AAP35978 CR533484 CAG38515 DB465491 DQ893536 ABM84462 DQ896800 ABM87799 NM_006717 NP_006708
|
| Function |
Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleolus.
|
| Tissue Specificity |
Highly expressed in ovarian cancer tissues. {ECO:0000269|PubMed:22258766}.
|