SPIN1

Gene Symbol SPIN1
Entrez Gene 10927
Alt Symbol SPIN
Species Human
Gene Type protein-coding
Description spindlin 1
Other Description ovarian cancer-related protein|spindlin-1|spindlin1
Swissprots Q7KZJ8 B3KRQ4 A8K0X6 Q9Y657 Q9H0N7 Q9GZT2
Accessions EAW62753 EAW62754 EAW62755 Q9Y657 AF087864 AAG48367 AF106682 AAD43035 AF317228 AAG38112 AJ420427 AK024590 AK027044 AK092017 BAG52466 AK289691 BAF82380 AK290009 BAF82698 AK315854 BAF98745 AL136719 CAB66653 AM392778 CAL37656 AM393748 CAL38623 BC013571 BC114515 AAI14516 BC114565 AAI14566 BT007314 AAP35978 CR533484 CAG38515 DB465491 DQ893536 ABM84462 DQ896800 ABM87799 NM_006717 NP_006708
Function Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (PubMed:24589551). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (PubMed:21960006). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. {ECO:0000269|PubMed:21960006, ECO:0000269|PubMed:22258766, ECO:0000269|PubMed:24589551}.
Subcellular Location Nucleus. Nucleus, nucleolus.
Tissue Specificity Highly expressed in ovarian cancer tissues. {ECO:0000269|PubMed:22258766}.

SPIN1 CRISPR/Cas9 KO Plasmid (h) - sc-407164 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 HDR Plasmid (h) - sc-407164-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 Double Nickase Plasmid (h) - sc-407164-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 Double Nickase Plasmid (h2) - sc-407164-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 CRISPR Activation Plasmid (h) - sc-407164-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 CRISPR Activation Plasmid (h2) - sc-407164-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 Lentiviral Activation Particles (h) - sc-407164-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 Lentiviral Activation Particles (h2) - sc-407164-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SPIN1 siRNA (h) - sc-92696 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPIN1 shRNA Plasmid (h) - sc-92696-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SPIN1 shRNA (h) Lentiviral Particles - sc-92696-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU050331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20473 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20473 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SPIN1 siRNA (Human) - CRH7453 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPIN1 - MBS8201055 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SPIN1 (NM_006717.2) - SHH416680 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human SPIN1(NM_006717.2) - SHL028686 from Creative biogene

Category siRNA
Species Reactivities Human

Human SPIN1 siRNA - orb267955 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SPIN1 shRNA Plasmid (Human) - CHH7453 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SPIN1 miRNA 3'UTR clone - MiUTR1H-09839 from Creative biogene

Species Reactivities Human
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