| Gene Symbol |
CUL9
|
| Entrez Gene |
23113
|
| Alt Symbol |
H7AP1, PARC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cullin 9
|
| Other Description |
CUL-9|UbcH7-associated protein 1|cullin-9|p53-associated parkin-like cytoplasmic protein|parkin-like cytoplasmic p53 binding protein
|
| Swissprots |
Q9BU56 Q8N3W9 Q68CP2 O75188 Q5TCY3 Q8IWT3 Q68D92
|
| Accessions |
CCQ43486 EAX04163 EAX04164 Q8IWT3 AB014608 BAA31683 AJ318215 CAC85756 AK125228 BAC86090 AK128364 AK129649 BAC85207 AY145132 AAN61516 AY927523 BC002879 AAH02879 BC017747 BC028159 AAH28159 BC148597 AAI48598 CR749511 CAH18328 CR749841 CAH18696 XM_011514422 XP_011512724 XM_011514423 XP_011512725 XM_011514424 XP_011512726 XM_011514425 XP_011512727 XM_011514426 XP_011512728 XM_011514427 XP_011512729 XM_011514428 XP_011512730 XM_011514429 XP_011512731 XM_011514430 XP_011512732 XR_926122 XR_926123 NM_015089 NP_055904
|
| Function |
Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53- associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328). {ECO:0000269|PubMed:12526791, ECO:0000269|PubMed:17332328, ECO:0000269|PubMed:24793696}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:12526791}.
|
| Tissue Specificity |
Ubiquitously expressed in all tissues with highest expression in testis brain and kidney. {ECO:0000269|PubMed:12526791}.
|