PTGDR2

Gene Symbol PTGDR2
Entrez Gene 11251
Alt Symbol CD294, CRTH2, DL1R, DP2, GPR44
Species Human
Gene Type protein-coding
Description prostaglandin D2 receptor 2
Other Description G protein-coupled receptor 44|G-protein coupled receptor 44|chemoattractant receptor homologous molecule expressed on T helper type 2 cells|chemoattractant receptor-homologous molecule expressed on TH2 cells|putative G-protein coupled receptor 44
Swissprots Q4QRI6 Q9Y5Y4 O94765
Accessions AAD21055 EAW73902 Q9Y5Y4 AB008535 BAA74518 AF144308 AAD34539 AK291371 BAF84060 AK313849 AY507142 AAR92484 BC096841 AAH96841 NM_004778 NP_004769
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
Tissue Specificity Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269|PubMed:11168006, ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225, ECO:0000269|PubMed:9973380}.

DP2 (C-5) - sc-271898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DP2 (C-5): sc-271898. Western blot analysis of DP2 expression in Jurkat (A) and Caki-1 (B) whole cell lysates.

DP2 (BM16) - sc-21798 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rat
Clonality Monoclonal
DP2 (BM16) PE: sc-21798 PE. FCM analysis of human peripheral blood leukocytes. Black line histogram represents the isotype control, normal rat IgG<sub>2a</sub>: sc-2872.

DP2 (V-16) - sc-23092 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DP2 (V-16): sc-23092. Western blot analysis of DP2 expression in Caki-1 whole cell lysate.

Anti-GPCR GPR44 antibody - ab190506 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GPCR GPR44 antibody (ab190506) at 1 µg/mlLane 1 : Human small intestine tissue lysateLane 2 : Human small intestine tissue lysate with blocking peptideLysates/proteins at 15 µg per lane.

Anti-GPCR GPR44 antibody - ab113224 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab113224, at 10µg/ml, staining GPCR GPR44 in Formalin-fixed, Paraffin-embedded Human Liver tissue by Immunohistochemistry.

Anti-GPCR GPR44 antibody - ab190636 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR44 antibody (ab190636) at 1/500 dilution + 293 cell lysate at 30 µg

Anti-GPCR GPR44 antibody - ab6029 from Abcam

Prices $370.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GPCR GPR44 antibody - ab46931 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GPCR GPR44 antibody (ab46931) at 1/500 dilution + GPR44 transfected Jurkat cells

Anti-GPCR GPR44 antibody [MM07098F56] - ab201646 from Abcam

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM07098F56

Anti-GPCR GPR44 antibody - Extracellular domain - ab150632 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human nasal mucosa tissue (eosinophils) labelling GPCR GPR44 with ab150632 at 32 &microg/ml after heat-induced antigen retrieval.

Anti-GPCR GPR44 antibody - N-terminal - ab188998 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed paraffin-embedded Human nasal mucosa sections (eosinophils) labeling GPCR GPR44 using ab188998 at 10 µg/ml.

Anti-GPR44 / CRTH2 Antibody (N-Terminus) IHC-plus™ - LS-B3209 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR44 / CRTH2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3209 concentration 5 ug/ml.

Anti-GPR44 / CRTH2 Antibody (C-Terminus) IHC-plus™ - LS-A153 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR44 / CRTH2 antibody LS-A153 IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR44 / CRTH2 Antibody (N-Terminus) IHC-plus™ - LS-A3528 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE)

Anti-GPR44 / CRTH2 Antibody - LS-C6222 from LifeSpan Bioscience

Prices $325.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody - LS-C40627 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody (aa15-33) - LS-C40711 from LifeSpan Bioscience

Prices $275.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody - LS-C83465 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody (N-Terminus) - LS-C127562 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody (aa329-348) - LS-C83753 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GPR44 / CRTH2 Antibody (aa329-348) IHC-plus™ - LS-B4755 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR44 / CRTH2 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4755 concentration 10 ug/ml.

Anti-GPR44 / CRTH2 Antibody (Extracellular Domain) IHC-plus™ - LS-A3529 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR44 / CRTH2 antibody LS-A3529 IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR44 / CRTH2 Antibody (Internal) - LS-C19673 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CRTH2 in Human Heart cells with CRTH2 antibody at 20 ug/ml.

Anti-GPR44 / CRTH2 Antibody (Extracellular Domain) IHC-plus™ - LS-A3530 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-GPR44 / CRTH2 antibody LS-A3530 IHC of human nasal mucosa, eosinophils. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-GPR44 / CRTH2 Antibody (Internal) - LS-C201034 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of PTGDR2 in human small intestine tissue with PTGDR2 antibody at 20 ug/ml.
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