PTGDR2

Gene Symbol PTGDR2
Entrez Gene 11251
Alt Symbol CD294, CRTH2, DL1R, DP2, GPR44
Species Human
Gene Type protein-coding
Description prostaglandin D2 receptor 2
Other Description G protein-coupled receptor 44|G-protein coupled receptor 44|chemoattractant receptor homologous molecule expressed on T helper type 2 cells|chemoattractant receptor-homologous molecule expressed on TH2 cells|putative G-protein coupled receptor 44
Swissprots Q4QRI6 Q9Y5Y4 O94765
Accessions AAD21055 EAW73902 Q9Y5Y4 AB008535 BAA74518 AF144308 AAD34539 AK291371 BAF84060 AK313849 AY507142 AAR92484 BC096841 AAH96841 NM_004778 NP_004769
Function Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
Tissue Specificity Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269|PubMed:11168006, ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225, ECO:0000269|PubMed:9973380}.

DP2 CRISPR/Cas9 KO Plasmid (h) - sc-404990 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 HDR Plasmid (h) - sc-404990-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 Double Nickase Plasmid (h) - sc-404990-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 Double Nickase Plasmid (h2) - sc-404990-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 CRISPR Activation Plasmid (h) - sc-404990-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 CRISPR Activation Plasmid (h2) - sc-404990-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 Lentiviral Activation Particles (h) - sc-404990-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 Lentiviral Activation Particles (h2) - sc-404990-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

DP2 siRNA (h) - sc-39838 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DP2 shRNA Plasmid (h) - sc-39838-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

DP2 shRNA (h) Lentiviral Particles - sc-39838-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CRTH-2/GPR44 RNAi - H00011251-R02 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU160991 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN2241 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2241 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PTGDR2 siRNA (Human) - CRH7712 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human PTGDR2 (NM_004778.2) - SHH385956 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human GPR44(NM_004778.2) - SHH100217 from Creative biogene

Category siRNA
Species Reactivities Human

PTGDR2 shRNA Plasmid (Human) - CHH7712 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PTGDR2 miRNA 3'UTR clone - MiUTR1H-04217 from Creative biogene

Species Reactivities Human
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