| Gene Symbol |
PTGDR2
|
| Entrez Gene |
11251
|
| Alt Symbol |
CD294, CRTH2, DL1R, DP2, GPR44
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prostaglandin D2 receptor 2
|
| Other Description |
G protein-coupled receptor 44|G-protein coupled receptor 44|chemoattractant receptor homologous molecule expressed on T helper type 2 cells|chemoattractant receptor-homologous molecule expressed on TH2 cells|putative G-protein coupled receptor 44
|
| Swissprots |
Q4QRI6 Q9Y5Y4 O94765
|
| Accessions |
AAD21055 EAW73902 Q9Y5Y4 AB008535 BAA74518 AF144308 AAD34539 AK291371 BAF84060 AK313849 AY507142 AAR92484 BC096841 AAH96841 NM_004778 NP_004769
|
| Function |
Receptor for prostaglandin D2 (PGD2). Coupled to the G(i)-protein. Receptor activation may result in pertussis toxin- sensitive decreases in cAMP levels and Ca(2+) mobilization. PI3K signaling is also implicated in mediating PTGDR2 effects. PGD2 induced receptor internalization. CRTH2 internalization can be regulated by diverse kinases such as, PKC, PKA, ADRBK1/GRK2, GPRK5/GRK5 and GRK6. Receptor activation is responsible, at least in part, in immune regulation and allergic/inflammation responses. {ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:11535533, ECO:0000269|PubMed:17196174}.
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Note=Internalized receptors colocalized with RAB11A. {ECO:0000269|PubMed:17207480}.
|
| Tissue Specificity |
Widespread expression. High expression in stomach, small intestine, heart and thymus. Intermediate expression in colon, spinal cord and peripheral blood and low expression in brain, skeletal muscle and spleen. Expressed also on Th2- and Tc2- type cells, eosinophils and basophils. {ECO:0000269|PubMed:11168006, ECO:0000269|PubMed:11208866, ECO:0000269|PubMed:12466225, ECO:0000269|PubMed:9973380}.
|
![Western Blot: GPR44 Overexpression Lysate (Adult Normal) [NBL1-11281] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for GPR44.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12294_GPR44%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-11281-img0002.jpg)