GPR161

Gene Symbol	GPR161
Entrez Gene	23432
Alt Symbol	RE2
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor 161
Other Description	G-protein coupled receptor 161|G-protein coupled receptor RE2
Swissprots	Q5TGK1 F5GXD6 B7Z5E8 Q5TGK0 O75963 Q8N6U8 Q5TGK2 F5H6J7 B7Z5Z6 B3KV34 B7Z5D7
Accessions	EAW90818 EAW90819 Q8N6U8 AA662800 AF091890 AAC61598 AK026059 AK056040 BAG51611 AK091271 BAC03624 AK091869 AK095302 AK122656 BAG53646 AK298797 BAH12873 AK298850 BAH12884 AK299634 BAH13082 AK310019 AY275468 AAP32300 BC028163 AAH28163 DQ893369 ABM84295 DQ896689 ABM87688 XM_005245055 XP_005245112 XM_005245056 XP_005245113 XM_005245057 XP_005245114 XM_006711251 XP_006711314 XM_006711252 XP_006711315 XM_006711253 XP_006711316 XM_011509370 XP_011507672 XM_011509371 XP_011507673 XM_011509372 XP_011507674 XM_011509373 XP_011507675 XM_011509374 XP_011507676 XM_011509375 XP_011507677 XM_011509376 XP_011507678 XM_011509377 XP_011507679 XM_011509378 XP_011507680 NM_007369 NM_001267609 NP_001254538 NM_001267610 NP_001254539 NM_001267611 NP_001254540 NM_001267612 NP_001254541 NM_001267613 NP_001254542 NM_001267614 NP_001254543 NM_153832 NP_722561
Function	Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity). {ECO:0000250}.
Subcellular Location	Cell projection, cilium membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

GPR161 (I-13) - sc-131525 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GPR161 (K-12) - sc-131526 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

GPR161 (P-23) - sc-101966 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (C-Terminus) IHC-plus™ - LS-A333 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (N-Terminus) IHC-plus™ - LS-A331 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (aa360-409) - LS-C101960 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (N-Terminus) - LS-C31890 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (C-Terminus) - LS-C31917 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (FITC) - LS-C211635 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (aa201-250) - LS-C40381 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (aa362-461) - LS-C307615 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-GPR161 Antibody - LS-C211631 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (HRP) - LS-C211636 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A332 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-GPR161 Antibody (Biotin) - LS-C211637 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

GPR161 Antibody - NBP1-60122 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody - NBP1-69244 from Novus Biologicals Prices $299.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody - NLS331 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody - NBP1-87146 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody - NLS333 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody - NLS332 from Novus Biologicals Prices $329.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

GPR161 Antibody (1B2) - H00023432-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1B2

GPR161 Polyclonal Antibody - bs-15385R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GPR161 antibody produced in rabbit - HPA015576 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-GPR161 (AB1) antibody produced in rabbit - AV42353 from Sigma-Aldrich Prices $267.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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