| Gene Symbol |
PLXNA2
|
| Entrez Gene |
5362
|
| Alt Symbol |
OCT, PLXN2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
plexin A2
|
| Other Description |
plexin 2|plexin-A2|semaphorin receptor OCT|transmembrane protein OCT
|
| Swissprots |
Q9BRL1 Q96GN9 Q6UX61 B2RMX7 A2RTX9 O75051 Q9UIW1
|
| Accessions |
EAW93457 O75051 AB007932 BAA32308 AK021813 BAB13902 AK055196 BAB70871 AK094259 AK094367 AK125154 AL544219 AY358496 AAQ88860 BC006193 AAH06193 BC009343 AAH09343 BC032125 BC094835 BC132676 AAI32677 BC136530 AAI36531 DA500239 H11743 X87831 CAB57275 XM_005273164 XP_005273221 XM_005273165 XP_005273222 XM_006711387 XP_006711450 NM_025179 NP_079455
|
| Function |
Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Detected in fetal brain. {ECO:0000269|PubMed:8570614}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: Plexin A2 Overexpression Lysate (Adult Normal) [NBP2-06232] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Plexin A2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6656_Plexin%2520A2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-06232-img0001.jpg)