Gene Symbol | PLXNA2 |
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Entrez Gene | 5362 |
Alt Symbol | OCT, PLXN2 |
Species | Human |
Gene Type | protein-coding |
Description | plexin A2 |
Other Description | plexin 2|plexin-A2|semaphorin receptor OCT|transmembrane protein OCT |
Swissprots | Q9BRL1 Q96GN9 Q6UX61 B2RMX7 A2RTX9 O75051 Q9UIW1 |
Accessions | EAW93457 O75051 AB007932 BAA32308 AK021813 BAB13902 AK055196 BAB70871 AK094259 AK094367 AK125154 AL544219 AY358496 AAQ88860 BC006193 AAH06193 BC009343 AAH09343 BC032125 BC094835 BC132676 AAI32677 BC136530 AAI36531 DA500239 H11743 X87831 CAB57275 XM_005273164 XP_005273221 XM_005273165 XP_005273222 XM_006711387 XP_006711450 NM_025179 NP_079455 |
Function | Coreceptor for SEMA3A and SEMA6A. Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down- stream signaling events in the cytoplasm (By similarity). {ECO:0000250}. |
Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
Tissue Specificity | Detected in fetal brain. {ECO:0000269|PubMed:8570614}. |
Top Pathways | Axon guidance |
plexin-A2 CRISPR/Cas9 KO Plasmid (h) - sc-403886 from Santa Cruz Biotechnology
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plexin-A2 HDR Plasmid (h) - sc-403886-HDR from Santa Cruz Biotechnology
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plexin-A2 Double Nickase Plasmid (h) - sc-403886-NIC from Santa Cruz Biotechnology
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plexin-A2 Double Nickase Plasmid (h2) - sc-403886-NIC-2 from Santa Cruz Biotechnology
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plexin-A2 CRISPR Activation Plasmid (h) - sc-403886-ACT from Santa Cruz Biotechnology
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plexin-A2 CRISPR Activation Plasmid (h2) - sc-403886-ACT-2 from Santa Cruz Biotechnology
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plexin-A2 Lentiviral Activation Particles (h) - sc-403886-LAC from Santa Cruz Biotechnology
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plexin-A2 Lentiviral Activation Particles (h2) - sc-403886-LAC-2 from Santa Cruz Biotechnology
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plexin-A2 siRNA (h) - sc-42172 from Santa Cruz Biotechnology
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plexin-A2 shRNA Plasmid (h) - sc-42172-SH from Santa Cruz Biotechnology
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plexin-A2 shRNA (h) Lentiviral Particles - sc-42172-V from Santa Cruz Biotechnology
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Plexin A2 RNAi - H00005362-R02 from Novus Biologicals
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MISSION® esiRNA - EHU119441 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17010 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17010 from Sigma-Aldrich
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PLXNA2 siRNA (Human) - CRH3600 from Cohesion Biosciences
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shRNA set against Human PLXNA2 (NM_025179.3) - SHH378200 from Creative biogene
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shRNA set against Human PLXNA2(NM_025179.3) - SHR105446 from Creative biogene
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Human PLXNA2 siRNA - orb264102 from Biorbyt
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PLXNA2 shRNA Plasmid (Human) - CHH3600 from Cohesion Biosciences
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PLXNA2 miRNA 3'UTR clone - MiUTR1H-08019 from Creative biogene
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