DIO2

Gene Symbol	DIO2
Entrez Gene	1734
Alt Symbol	5DII, D2, DIOII, SelY, TXDI2
Species	Human
Gene Type	protein-coding
Description	deiodinase, iodothyronine, type II
Other Description	deiodinase-2\|deiodonase-2\|thyroxine deiodinase, type II\|type 2 DI\|type 2 iodothyronine deiodinase\|type II iodothyronine deiodinase\|type-II 5'-deiodinase\|type-II 5'deiodinase
Swissprots	Q6B0A3 Q9UDZ1 Q9P1W4 G3V315 Q92813 Q9HCP8 B9EGK0
Accessions	AAD45494 AAF37612 BAB21594 EAW81320 EAW81321 EAW81322 EAW81323 EAW81324 EAW81325 Q92813 AB041843 BAB16838 AB041844 BAB16839 AF007144 AF093774 AAC95470 AF123661 AI248279 AI697311 AI701403 AI888658 AK292210 BAF84899 AK311603 BC063118 AAH63118 BC074882 AAH74882 BC136514 AAI36515 BF224328 CD691767 CD701270 U53506 AAC50663 NM_000793 NP_000784 NM_001007023 NP_001007024 NM_001242502 NP_001229431 NM_001242503 NP_001229432 NM_013989 NP_054644
Function	Responsible for the deiodination of T4 (3,5,3',5'- tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.
Subcellular Location	Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Tissue Specificity	Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.

DIO2 (C-18) - sc-69558 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

DIO2 (G-16) - sc-69560 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

DIO2 (D-19) - sc-69559 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

DIO2 (H-165) - sc-98716 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

DIO2 (H-165): sc-98716. Western blot analysis of DIO2 expression in human skeletal muscle tissue extract.

DIO2 (P-20) - sc-69561 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-DIO2 antibody - ab135711 from Abcam

Prices	$384.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 antibody (ab135711) at 1/100 dilution + MCF7 cell line lysate at 35 µg

Anti-DIO2 Antibody (Internal, AP) - LS-C276768 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (Internal, APC) - LS-C276770 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (Internal, Biotin) - LS-C276769 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa217-228) - LS-C61730 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

DIO2 antibody (2 ug/ml) staining of PFA-fixed cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.

Anti-DIO2 Antibody (Internal, Azide-free, HRP) - LS-C276772 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (Internal, FITC) - LS-C276771 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (Internal, PE) - LS-C276773 from LifeSpan Bioscience

Prices	$515.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa30-259, Biotin) - LS-C300434 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa30-259, FITC) - LS-C303764 from LifeSpan Bioscience

Prices	$475.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (Internal) - LS-C327196 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa30-259) - LS-C293664 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa30-259) - LS-C314935 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-DIO2 Antibody (aa165-191) - LS-C167417 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

DIO2 Antibody IHC of formalin-fixed and paraffin-embedded mouse brain followed by peroxidase-conjugated secondary antibody and DAB staining. This data demonstrates the use of the mouse DIO2 Antibody for immunohistochemistry.

DIO2 Antibody - NBP1-00178 from Novus Biologicals

Prices	$329.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

DIO2 Antibody - NBP1-80770 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: DIO2 Antibody [NBP1-80770] - staining of human cell line U-2 OS shows positivity in cytoplasm.

DIO2 Polyclonal Antibody - bs-3673R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Paraformaldehyde-fixed, paraffin embedded Mouse stomach; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with DIO2 Polyclonal Antibody, Unconjugated (bs-3673R) at 1:400 overnight at 4°C, followed by a conjugated secondary antibody for 20 minutes and DAB staining.

Anti-DIO2 antibody produced in goat - SAB2500310 from Sigma-Aldrich

Prices	$376.00
Sizes	100 µg
Host	Goat
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-DIO2: <B>Cat. No. SAB2500310</B>: (2 μg/mL) staining of cryo-sectioned Mouse Hippocampus. Microwaved antigen retrieval with citrate buffer pH 4.5, HRP-staining.

ANTI-DIO2 (CENTER) antibody produced in rabbit - SAB1303197 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>DIO2 (Center): <B>Cat. No. SAB1303197</B>: DIO2 in Human brain tissue with DIO2 antibody (Center) at 5 μg/mL.

Anti-DIO2 antibody produced in rabbit - HPA029544 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-DIO2: <B>Cat. No. HPA029544</B>: Immunohistochemical staining of human stomach shows strong cytoplasmic positivity in parietal cells.

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