| Gene Symbol |
RNF2
|
| Entrez Gene |
6045
|
| Alt Symbol |
BAP-1, BAP1, DING, HIPI3, RING1B, RING2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 2
|
| Other Description |
E3 ubiquitin-protein ligase RING2|HIP2-interacting protein 3|RING finger protein 1B|RING finger protein BAP-1|huntingtin-interacting protein 2-interacting protein 3|protein DinG
|
| Swissprots |
B2RBS7 Q5TEN2 Q5TEN1 Q99496 B3KRH1
|
| Accessions |
EAW91187 EAW91188 Q99496 AF075026 AF141327 AAD29717 AI242656 AK091574 BAG52383 AK314793 BAG37324 BC012583 AAH12583 BF183837 BX338357 DQ892932 ABM83858 DQ896181 ABM87180 Y10571 CAA71596 XM_005245413 XP_005245470 XM_011509851 XP_011508153 XM_011509852 XP_011508154 NM_007212 NP_009143
|
| Function |
E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB le
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}.
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