RNF2

Gene Symbol	RNF2
Entrez Gene	6045
Alt Symbol	BAP-1, BAP1, DING, HIPI3, RING1B, RING2
Species	Human
Gene Type	protein-coding
Description	ring finger protein 2
Other Description	E3 ubiquitin-protein ligase RING2|HIP2-interacting protein 3|RING finger protein 1B|RING finger protein BAP-1|huntingtin-interacting protein 2-interacting protein 3|protein DinG
Swissprots	B2RBS7 Q5TEN2 Q5TEN1 Q99496 B3KRH1
Accessions	EAW91187 EAW91188 Q99496 AF075026 AF141327 AAD29717 AI242656 AK091574 BAG52383 AK314793 BAG37324 BC012583 AAH12583 BF183837 BX338357 DQ892932 ABM83858 DQ896181 ABM87180 Y10571 CAA71596 XM_005245413 XP_005245470 XM_011509851 XP_011508153 XM_011509852 XP_011508154 NM_007212 NP_009143
Function	E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB le
Subcellular Location	Nucleus {ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Ring1b CRISPR/Cas9 KO Plasmid (h) - sc-404633 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b HDR Plasmid (h) - sc-404633-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b Double Nickase Plasmid (h) - sc-404633-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b Double Nickase Plasmid (h2) - sc-404633-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b CRISPR Activation Plasmid (h) - sc-404633-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b CRISPR Activation Plasmid (h2) - sc-404633-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b Lentiviral Activation Particles (h) - sc-404633-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b Lentiviral Activation Particles (h2) - sc-404633-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RING1B siRNA (h) - sc-62946 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RING1B shRNA Plasmid (h) - sc-62946-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RING1B shRNA (h) Lentiviral Particles - sc-62946-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RNF2 RNAi - H00006045-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

RNF2 RNAi - H00006045-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU109061 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18414 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18414 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RNF2 siRNA (Human) - CRH4092 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RNF2 - MBS8224649 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Ring1b CRISPR/Cas9 KO Plasmid (h2) - sc-404633-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Ring1b HDR Plasmid (h2) - sc-404633-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human RNF2 (NM_007212.3) - SHH397088 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RNF2(NM_007212.3) - SHG091142 from Creative biogene Category siRNA Species Reactivities Human

Human RNF2 siRNA - orb264594 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RNF2 shRNA Plasmid (Human) - CHH4092 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RNF2 miRNA 3'UTR clone - MiUTR1H-08897 from Creative biogene Species Reactivities Human

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