RNF2

Gene Symbol	RNF2
Entrez Gene	6045
Alt Symbol	BAP-1, BAP1, DING, HIPI3, RING1B, RING2
Species	Human
Gene Type	protein-coding
Description	ring finger protein 2
Other Description	E3 ubiquitin-protein ligase RING2|HIP2-interacting protein 3|RING finger protein 1B|RING finger protein BAP-1|huntingtin-interacting protein 2-interacting protein 3|protein DinG
Swissprots	B2RBS7 Q5TEN2 Q5TEN1 Q99496 B3KRH1
Accessions	EAW91187 EAW91188 Q99496 AF075026 AF141327 AAD29717 AI242656 AK091574 BAG52383 AK314793 BAG37324 BC012583 AAH12583 BF183837 BX338357 DQ892932 ABM83858 DQ896181 ABM87180 Y10571 CAA71596 XM_005245413 XP_005245470 XM_011509851 XP_011508153 XM_011509852 XP_011508154 NM_007212 NP_009143
Function	E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB le
Subcellular Location	Nucleus {ECO:0000269|PubMed:21282530}. Chromosome {ECO:0000250}. Note=Enriched on inactive X chromosome (Xi) in female trophoblast stem (TS) cells as well as differentiating embryonic stem (ES) cells. The enrichment on Xi is transient during TS and ES cell differentiation. The association with Xi is mitotically stable in non-differentiated TS cells (By similarity). {ECO:0000250}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RING2 / RING1B / RNF2 full length protein - ab159360 from Abcam Category Protein Source Wheat germ Species Human

Human RING2 / RING1B / RNF2 protein fragment - ab159361 from Abcam Category Protein Source Wheat germ Species Human

RNF2 / RING2 / RING1B Antibody Blocking Peptide - LS-E25494 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RNF2 / RING2 / RING1B Antibody Blocking Peptide - LS-E12136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF2 Protein - H00006045-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RNF2 Protein - H00006045-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF2 blocking peptide - GTX14751-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Bovine

RNF2 Immunizing peptide - orb17743 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

RING2 / RING1B / RNF2 Peptide - AC21-0323-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RNF2 - H00006045-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RNF2 - H00006045-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RNF2 - H00006045-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF2 - H00006045-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF2 Peptide - 46-304P from ProSci Category Peptide Species Human

RNF2 fusion protein - Ag8900 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RNF2 fusion protein - Ag9129 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RNF2, GST-tagged - RNF2-2341H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase RING2(RNF2) - CSB-YP859101HU CSB-EP859101HU CSB-BP859101HU CSB-MP859101HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF2 - TP303089 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RNF2/dinG, Peptide - MBS425284 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Dog, Bovine

RNF2 Recombinant Protein Antigen - NBP1-88712PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF2-Blocking-Peptide-Center - BP21209c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF2 Peptide, Human - M34GP13414H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase RING2 (RNF2), Recombinant Protein - MBS1358314 from MyBioSource Category Protein Prices $1,100.00, $1,100.00, $1,325.00, $1,325.00, $1,730.00, $1,730.00, $2,195.00, $2,195.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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